دورية أكاديمية
The effect of Momordica charantia intake on the estrogen receptors ESR alpha/ESR beta gene levels and apoptosis on uterine tissue in ovariectomy rats
| العنوان: | The effect of Momordica charantia intake on the estrogen receptors ESR alpha/ESR beta gene levels and apoptosis on uterine tissue in ovariectomy rats |
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| المؤلفون: | Cevik, Ozge, Akpinar, Hikmet, Oba, Rabia, Cilingir, Ozlem Tugce, Ozdemir, Zarife Nigar, Cetinel, Sule, Yoldemir, Tevfik |
| المساهمون: | Cevik, Ozge Cumhuriyet Univ, Dept Biochem, Fac Pharm, Sivas, Turkey -- Akpinar, Hikmet -- Oba, Rabia Marmara Univ, Dept Biochem, Fac Pharm, Istanbul, Turkey -- Cilingir, Ozlem Tugce -- Cetinel, Sule Marmara Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkey -- Ozdemir, Zarife Nigar Marmara Univ, Sch Med, Dept Physiol, Istanbul, Turkey -- Yoldemir, Tevfik Marmara Univ, Sch Med, Dept Obstet & Gynecol, Istanbul, Turkey, Cilingir Kaya, Ozlem Tugce -- 0000-0002-2591-9174, Cevik, Ozge -- 0000-0002-9325-3757 |
| بيانات النشر: | SPRINGER |
| سنة النشر: | 2015 |
| المجموعة: | Sivas Cumhuriyet University Institutional Repository |
| مصطلحات موضوعية: | Momordica charantia, Overectomy, 17-beta Estradiol, Estrogen receptors, Oxidative DNA damage, Apoptosis |
| الوصف: | WOS: 000349006400018 ; PubMed ID: 25253099 ; Estrogen or combinational hormone therapy can protect to menopausal symptoms but exogenous estrogen therapy has some potential risks which in turns lead to the appearance of various diseases. In recent years plants with high phytoestrogen content are recommended as therapeutic agents for postmenopausal hormonal treatment. In this research, we investigated the effects of Momordica charantia (MC) on the estrogen production and E2 as well as anti-oxidative and anti-apoptotic role on the ovariectomy rat model. The rats were ovariectomized and fed on 2 g/kg of fruit extra of MC for 30 days by gavage. 17-beta estradiol (E2) and 8-OHdG levels in serum, markers of oxidative damage of ROS and ESR alpha, ESR beta and NF-kB gene levels were measured in uterus horn tissue. Caspase-3, caspase-9, TNF-alpha, IL-6, IL-10, Bcl-2 and Nf-kB proteins expression were assessed by western blotting. Structural changes in tissue were examined with H&E staining. MC administration also stimulated the E2 production and ESR alpha/ESR beta gene levels and the inhibited oxidative damage. Furthermore, MC treatment enhanced anti-apoptotic and anti-inflammatory process and tissue regeneration. Data herein support that MC directly regulates uterine estrogen response and may serve as a new phytoestrogenic substance for the treatment of post-menopausal symptoms. ; Marmara University Scientific Research Project Coordination [SAG-C-YLP 101012-0315] ; The research funded from Marmara University Scientific Research Project Coordination with grant number (SAG-C-YLP 101012-0315). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0301-4851 1573-4978 |
| العلاقة: | MOLECULAR BIOLOGY REPORTS; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1007/s11033-014-3756-7Test; https://hdl.handle.net/20.500.12418/8057Test; 42; 177; 167 |
| DOI: | 10.1007/s11033-014-3756-7 |
| الإتاحة: | https://doi.org/20.500.12418/8057Test https://doi.org/10.1007/s11033-014-3756-7Test https://hdl.handle.net/20.500.12418/8057Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.701B10B2 |
| قاعدة البيانات: | BASE |
| تدمد: | 03014851 15734978 |
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| DOI: | 10.1007/s11033-014-3756-7 |