دورية أكاديمية
Genetic Polymorphisms of Sulfotransferases (SULT1A1 and SULT1A2) in a Turkish Population
| العنوان: | Genetic Polymorphisms of Sulfotransferases (SULT1A1 and SULT1A2) in a Turkish Population |
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| المؤلفون: | Arslan, Serdal |
| المساهمون: | Cumhuriyet Univ, Fac Sci & Literature, Dept Mol Biol & Genet, TR-58140 Sivas, Turkey |
| بيانات النشر: | SPRINGER/PLENUM PUBLISHERS |
| سنة النشر: | 2010 |
| المجموعة: | Sivas Cumhuriyet University Institutional Repository |
| مصطلحات موضوعية: | Sulfotransferases, Linkage disequilibrium, SULT1A1, SULT1A2 |
| الوصف: | WOS: 000284331300010 ; PubMed ID: 20936502 ; Sulfotransferases (SULTs) play a significant role in the biotransformation of a variety of xenobiotics and endogenous compounds. SULTs are genetically polymorphic enzymes; to date, 12 human cytosolic SULT isoforms have been identified. This study investigated SULT1A1 and SULT1A2 gene polymorphism using a PCR-RFLP method (n = 303). The frequency of the SULT1A1*1 allele was 76.2% and SULT1A1*2 was 23.8%. The SULT1A1*3 allele could not be identified. The SULT1A2 frequencies were 69.2% (SULT1A2*1), 18.3% (SULT1A2*2), and 12.5% (SULT1A2*3). The SULT1A1 and SULT1A2 loci were in Hardy-Weinberg equilibrium (SULT1A1 chi(2) = 0.58, P = 0.44; SULT1A2 chi(2) = 7.28, P = 0.06). Linkage analysis indicated a close linkage between these two genes (chi(2) = 5.31, P < 0.01); therefore, the statistical hypothesis that SULT1A1 and SULT1A2 alleles are independently distributed was rejected. Additionally, a strongly positive linkage was detected between SULT1A1*2 and SULT1A2*2 alleles in this population (D' = 0.79, chi(2) = 33.33). ; Research Council of Cumhuriyet University (CUBAP), Sivas, Turkey [F-217] ; This study has been supported by the Research Council of Cumhuriyet University (CUBAP, Project No: F-217), Sivas, Turkey. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0006-2928 |
| العلاقة: | BIOCHEMICAL GENETICS; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1007/s10528-010-9387-3Test; https://hdl.handle.net/20.500.12418/9735Test; 48; 11.Dec; 994; 987 |
| DOI: | 10.1007/s10528-010-9387-3 |
| الإتاحة: | https://doi.org/20.500.12418/9735Test https://doi.org/10.1007/s10528-010-9387-3Test https://hdl.handle.net/20.500.12418/9735Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.75BCA7F8 |
| قاعدة البيانات: | BASE |
| تدمد: | 00062928 |
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| DOI: | 10.1007/s10528-010-9387-3 |