دورية أكاديمية
Effects of Malathion in Fetal Kidney Tissues in Pregnant Rats: Teratogenic Effects Induced by Different Doses
| العنوان: | Effects of Malathion in Fetal Kidney Tissues in Pregnant Rats: Teratogenic Effects Induced by Different Doses |
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| المؤلفون: | Alp, Harun, Sak, Muhammet Erdal, Evsen, Mehmet Siddik, Firat, Ugur, Evliyaoglu, Osman, Penbegul, Necmettin, Sancaktutar, Ahmet Ali, Soylemez, Haluk, Tuzcu, Mehmet |
| المساهمون: | Alp, Harun Mustafa Kemal Univ, Fac Med, Dept Pharm, TR-31040 Antakya, Turkey -- Sak, Muhammet Erdal -- Evsen, Mehmet Siddik Dicle Univ, Fac Med, Dept Obstet & Gynecol, TR-21280 Diyarbakir, Turkey -- Firat, Ugur Dicle Univ, Fac Med, Dept Pathol, TR-21280 Diyarbakir, Turkey -- Evliyaoglu, Osman Dicle Univ, Fac Med, Dept Biochem, Diyarbakir, Turkey -- Penbegul, Necmettin -- Sancaktutar, Ahmet Ali -- Soylemez, Haluk Dicle Univ, Fac Med, Dept Urol, TR-21280 Diyarbakir, Turkey -- Tuzcu, Mehmet Cumhuriyet Univ, Fac Vet, Dept Pathol, TR-58140 Sivas, Turkey, Evliya, Osman -- 0000-0002-5780-9068 |
| بيانات النشر: | KAFKAS UNIV, VETERINER FAKULTESI DERGISI |
| سنة النشر: | 2012 |
| المجموعة: | Sivas Cumhuriyet University Institutional Repository |
| مصطلحات موضوعية: | Fetus, Pregnant rat, Organophosphate, Prenatal exposure, Teratogenic effect |
| الوصف: | WOS: 000302198700009 ; The aim of this study was to investigate the teratogenic effects of Malathion (ML) induced by different doses on fetal kidney tissues in pregnant rats. A total of 28 Sprague-Dawley pregnant rats were randomly divided into 4 groups of 7 rats each. Depending on ML dose, four groups were formed, including (I) control, (II) ML 2.5 (ML 2.5 mg/kg/day, orally), (III) ML 5 (5 mg/kg/day, orally), and (IV) ML 10 (10 mg/kg/day, orally). ML application started when the male and female were put together (when mating started). Daily ML application was continued until birth. It was determined that in parallel with dose of ML, ML resulted in toxic effects on serum enzymes (acetyl-cholinesterase (AChE), amylase and lipase) and kidney tissues of pregnant rats, and also -regardless of ML dose in fetal kidneys-it led to teratogenic effects in all the doses. Biochemical data wasconfirmed by histopathologic data. We concluded that ML leads to kidney damage in both pregnant and fetal rats as a result of its teratogenic and toxic effects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1300-6045 |
| العلاقة: | KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.12418/9220Test; 18; 226; 221 |
| الإتاحة: | https://doi.org/20.500.12418/9220Test https://hdl.handle.net/20.500.12418/9220Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1A06A0DD |
| قاعدة البيانات: | BASE |
| تدمد: | 13006045 |
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