دورية أكاديمية
Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis.
| العنوان: | Relationship of flow-volume curve pattern on pulmonary function test with clinical and radiological features in idiopathic pulmonary fibrosis. |
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| المؤلفون: | NAKAGAWA Hiroaki, OTOSHI Ryota, ISOMOTO Kohsuke, KATANO Takuma, BABA Tomohisa, KOMATSU Shigeru, HAGIWARA Eri, NAKANO Yasutaka, KUWAHIRA Ichiro, OGURA Takashi, 仲川 宏昭, 中野 恭幸 |
| المصدر: | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7424671Test/. |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2020 |
| المجموعة: | Shiga University of Medical Science Repository BI WAKO / 滋賀医科大学機関リポジトリ |
| مصطلحات موضوعية: | Concave, Convex, Flow-volume curve, Honeycombing area, Idiopathic pulmonary fibrosis |
| الوصف: | Background:The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radiological features in IPF. ; Methods:The FV curves on PFTs and chest high-resolution computed tomography (HRCT) images of 130 patients with IPF were retrospectively evaluated. The FV curves were divided into four groups based on the presence or absence of the convex and concave patterns: convex/concave, non-convex/concave, convex/non-concave, and non-convex/non-concave. Using a computer-aided system, CT honeycombing area (%HA) and subtracted low attenuation area (%sLAA) were quantitatively measured. To assess the distribution of CT findings, the lung area was divided into upper, lower, central, and peripheral areas. The relationships of FV curve patterns with patient characteristics, spirometry results, and quantitative CT findings were evaluated. ; Results:The patients with convex pattern was identified in 93 (71.5%) and concave pattern in 72 (55.4%). Among the four groups, patients with the convex/non-concave pattern had significantly lower forced vital capacity (FVC) and higher %HA of the upper/peripheral lung area (p = 0.018, and p = 0.005, respectively). The convex/non-concave pattern was a significant predictor of mortality for IPF (hazard ratio, 2.19; p = 0.032). ; Conclusions:Patients with convex/non-concave pattern in FV curve have lower FVC and poorer prognosis with distinct distribution of fibrosis. Hence, FV curve pattern might be a useful predictor of mortality in IPF. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2466 |
| العلاقة: | https://doi.org/10.1186/s12890-020-01254-zTest; https://shiga-med.repo.nii.ac.jp/?action=repository_uri&item_id=3666Test; http://hdl.handle.net/10422/00012782Test; BMC pulmonary medicine, 20(1), 214(2020-08-12); https://shiga-med.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3666&item_no=1&attribute_id=17&file_no=1Test |
| الإتاحة: | https://doi.org/10.1186/s12890-020-01254-zTest http://hdl.handle.net/10422/00012782Test https://shiga-med.repo.nii.ac.jp/?action=repository_uri&item_id=3666Test https://shiga-med.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3666&item_no=1&attribute_id=17&file_no=1Test |
| حقوق: | © The Author(s). 2020 |
| رقم الانضمام: | edsbas.A635E4B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712466 |
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