دورية أكاديمية
Orexin deficiency modulates cognitive flexibility in a sex-dependent manner
| العنوان: | Orexin deficiency modulates cognitive flexibility in a sex-dependent manner |
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| المؤلفون: | Durairaja, Archana, Fendt, Markus |
| سنة النشر: | 2021 |
| المجموعة: | Share it - Open Access und Forschungsdaten-Repositorium der Hochschulbibliotheken in Sachsen-Anhalt |
| مصطلحات موضوعية: | ddc:610, Animal models of schizophrenia, Attentional set shifting, Anxiety, Cognitive flexibility, Food consumption, Learning and memory, Narcolepsy, Neuropeptides, Orexin, Transgenic mice |
| الوصف: | Cognitive flexibility is an important executive function and refers to the ability to adapt behaviors in response to changes in the environment. Of note, many brain disorders are associated with impairments in cognitive flexibility. Several classical neurotransmitter systems including dopamine, acetylcholine and noradrenaline are shown to be important for cognitive flexibility, however, there is not much known about the role of neuropeptides. The neuropeptide orexin, which is brain-widely released by neurons in the lateral hypothalamus, is a major player in maintaining sleep/wake cycle, feeding behavior, arousal, and motivational behavior. Recent studies showed a role of orexin in attention, cognition and stress-induced attenuation of cognitive flexibility by disrupting orexin signaling locally or systemically. However, it is not known so far whether brainwide reduction or loss of orexin affects cognitive flexibility. We investigated this question by testing male and female orexin-deficient mice in the attentional set shifting task (ASST), an established paradigm of cognitive flexibility. We found that orexin deficiency impaired the intra-dimensional shift phase of the ASST selectively in female homozygous orexin-deficient mice and improved the first reversal learning phase selectively in male homozygous orexin-deficient mice. We also found that these orexin-mediated sex-based modulations of cognitive flexibility were not correlated with trait anxiety, narcoleptic episodes, and reward consumption. Our findings highlight a sexually dimorphic role of orexin in regulating cognitive flexibility and the need for further investigations of sex-specific functions of the orexin circuitry. ; Projekt DEAL 2020 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-1-74528-571-6 1-74528-571-7 |
| العلاقة: | http://dx.doi.org/10.25673/85899Test; https://opendata.uni-halle.de//handle/1981185920/87852Test; urn:nbn:de:gbv:ma9:1-1981185920-878524 |
| DOI: | 10.25673/85899 |
| الإتاحة: | https://doi.org/10.25673/85899Test https://opendata.uni-halle.de//handle/1981185920/87852Test https://nbn-resolving.org/urn:nbn:de:gbv:ma9:1-1981185920-878524Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.ED251491 |
| قاعدة البيانات: | BASE |
| ردمك: | 9781745285716 1745285717 |
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| DOI: | 10.25673/85899 |