التفاصيل البيبلوغرافية
| العنوان: |
A Study of the Effect of Specific Antibacterial Therapy on the Course of Tuberculous Spondylitis in an Experiment ; Дослідження впливу специфічної антибактеріальної терапії на перебіг туберкульозного спондиліту в експерименті |
| المؤلفون: |
Голка, Г.Г., Веснін, В.В., Бурлака, В.В., Олійник, А.О., Фадєєв, О.Г., Гопцій, О.В., Фролова–Романюк, Е.Ю. |
| المصدر: |
Tuberculosis, Lung Diseases, HIV Infection; No. 1 (2024); 58-66 ; Туберкулез, легочные болезни, ВИЧ-инфекция; № 1 (2024); 58-66 ; Туберкульоз, легеневі хвороби, ВІЛ-інфекція; № 1 (2024); 58-66 ; 2522-1094 ; 2220-5071 |
| بيانات النشر: |
Private Enterprise INPOL LTM |
| سنة النشر: |
2024 |
| المجموعة: |
Scientific Periodicals of Ukraine (Ukrainian Research and Academic Network) / Наукова періодика України |
| مصطلحات موضوعية: |
experimental modeling of tuberculous spondylitis, antibacterial therapy, експериментальне моделювання туберкульозного спондиліту, антибактеріальна терапія |
| الوصف: |
Objective — to assess the impact of modern antibacterial therapy on the development of a specific destructive process in experimental tuberculous spondylitis in animals. Materials and methods. The experiments were conducted on 40 sexually mature guinea pigs (age over 6 months) with an average weight of 350—500 grams. Tuberculous spondylitis was induced using a proprietary method (Patent No. 112423 (UA) Ukraine).All experimental animals were divided into 4 equal groups. Groups 1—3 (main groups) received an injection of 0.5 ml of M. tuberculosis suspension (0.1 mg of dry weight in 1 ml) into the body of the vertebra, according to the specified method. Group 4 served as the control, receiving an injection of sterile physiological solution (0.9 % NaCl, 0.5 ml) into the vertebra.Specific first-line antibacterial drugs (ABDs) consisting of isoniazid, streptomycin, and rifampicin were administered to Group 1, which consisted of 10 guinea pigs. Group 2, also comprising 10 guinea pigs, received specific second-line ABDs, including amikacin, rifabutin and ofloxacin. Groups 3 and 4, each consisting of 10 guinea pigs, received no treatment. Results and discussion. The morphological analysis revealed the presence of an active tuberculosis process in the vertebral bodies and paravertebral tissues of animals subjected to tuberculosis simulation, regardless of whether they received specific first-line ABD treatment or not. Notably, the severity of destructive changes in affected vertebrae was similar between untreated animals and those treated with first-line ABDs.Animals modeled for tuberculosis and treated with specific second-line ABDs exhibited a suppression of the pathological process. This was evidenced by the formation of immature bone and connective tissue to varying degrees, along with the presence of a delineating zone separating the inflammatory focus from healthy tissue in the early stages of the disease (one month).Conclusions. Based on the histological examination of the vertebral bodies, it was established that ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://tubvil.com.ua/article/view/298790/291660Test; http://tubvil.com.ua/article/view/298790Test |
| الإتاحة: |
http://tubvil.com.ua/article/view/298790Test |
| حقوق: |
Авторське право (c) 2024 Автори ; https://creativecommons.org/licenses/by-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.2CBEB2AB |
| قاعدة البيانات: |
BASE |
