دورية أكاديمية
Novel Fredericamycin Variant Overproduced by a Streptomycin-Resistant Streptomyces albus subsp. chlorinus Strain
| العنوان: | Novel Fredericamycin Variant Overproduced by a Streptomycin-Resistant Streptomyces albus subsp. chlorinus Strain |
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| المؤلفون: | Rodríguez Estévez, Marta, Myronovskyi, Maksym, Rosenkränzer, Birgit, Paululat, Thomas, Petzke, Lutz, Ristau, Jeanette, Luzhetskyy, Andriy |
| بيانات النشر: | Saarländische Universitäts- und Landesbibliothek |
| سنة النشر: | 2020 |
| المجموعة: | SciDok - Der Wissenschaftsserver der UdS (Universität des Saarlandes) |
| مصطلحات موضوعية: | ddc:500, ddc:600, ddc:610, antitumor, fredericamycin, overproduction, secondary metabolites, streptomycetes, streptomycin-resistant, type II PKS |
| الوصف: | Streptomycetes are an important source of natural products potentially applicable in the pharmaceutical industry. Many of these drugs are secondary metabolites whose biosynthetic genes are very often poorly expressed under laboratory cultivation conditions. In many cases, antibiotic-resistant mutants exhibit increased production of natural drugs, which facilitates the identification and isolation of new substances. In this study, we report the induction of a type II polyketide synthase gene cluster in the marine strain Streptomyces albus subsp. chlorinus through the selection of streptomycin-resistant mutants, resulting in overproduction of the novel compound fredericamycin C2 (1). Fredericamycin C2 (1) is structurally related to the potent antitumor drug lead fredericamycin A. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1660-3397 |
| العلاقة: | http://www.mdpi.com/1660-3397/18/6/284/s1Test; Marine Drugs 18 (6): 284 (2020); http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-313563Test; hdl:20.500.11880/30404; http://dx.doi.org/10.22028/D291-31356Test |
| DOI: | 10.22028/D291-31356 |
| DOI: | 10.3390/md18060284 |
| الإتاحة: | https://doi.org/10.22028/D291-31356Test https://doi.org/10.3390/md18060284Test http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-313563Test |
| حقوق: | openAccess ; Attribution 4.0 International (CC BY 4.0) ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.D031F67F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16603397 |
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| DOI: | 10.22028/D291-31356 |