دورية أكاديمية
Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004
| العنوان: | Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004 |
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| المؤلفون: | Rasche, M., von Neuhoff, C., Dworzak, M., Bourquin, J.-P., Bradtke, J., Göhring, G., Escherich, G., Fleischhack, G., Graf, N., Gruhn, B., Haas, O. A., Klingebiel, T., Kremens, B., Lehrnbecher, T., von Stackelberg, A., Tchinda, J., Zemanova, Z., Thiede, C., von Neuhoff, N., Zimmermann, M., Creutzig, U., Reinhardt, D. |
| بيانات النشر: | Saarländische Universitäts- und Landesbibliothek |
| سنة النشر: | 2017 |
| المجموعة: | SciDok - Der Wissenschaftsserver der UdS (Universität des Saarlandes) |
| مصطلحات موضوعية: | ddc:610, Acute myeloid leukaemia, Cancer, Cancer genetics, Cytogenetics, Genetics research, Paediatric cancer, Prognostic markers |
| الوصف: | We conducted a cytogenetic analysis of 642 children with de novo acute myeloid leukemia (AML) treated on the AML-BerlinFrankfurt-Münster (BFM) 04 protocol to determine the prognostic value of specific chromosomal aberrations including monosomal (MK+ ), complex (CK+ ) and hypodiploid (HK+ ) karyotypes, individually and in combination. Multivariate regression analysis identified in particular MK+ (n = 22) as a new independent risk factor for poor event-free survival (EFS 23 ± 9% vs 53 ± 2% for all other patients, P = 0.0003), even after exclusion of four patients with monosomy 7 (EFS 28 ± 11%, P = 0.0081). CK+ patients without MK had a better prognosis (n = 47, EFS 47 ± 8%, P = 0.46) than those with MK+ (n = 12, EFS 25 ± 13%, P = 0.024). HK+ (n = 37, EFS 44 ± 8% for total cohort, P = 0.3) influenced outcome only when t(8;21) patients were excluded (remaining n = 16, EFS 9 ± 8%, Po0.0001). An extremely poor outcome was observed for MK+ /HK+ patients (n = 10, EFS 10 ± 10%, Po0.0001). Finally, isolated trisomy 8 was also associated with low EFS (n = 16, EFS 25 ± 11%, P = 0.0091). In conclusion, monosomal karyotype is a strong and independent predictor for high-risk pediatric AML. In addition, isolated trisomy 8 and hypodiploidy without t(8;21) coincide with dismal outcome. These results have important implications for risk stratification and should be further validated in independent pediatric cohorts. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1476-5551 0887-6924 |
| العلاقة: | https://static-content.springer.com/esm/art%3A10.1038%2Fleu.2017.121/MediaObjects/41375_2017_BFleu2017121_MOESM128_ESM.docxTest; http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-410627Test; hdl:20.500.11880/36851; http://dx.doi.org/10.22028/D291-41062Test |
| DOI: | 10.22028/D291-41062 |
| DOI: | 10.1038/leu.2017.121 |
| الإتاحة: | https://doi.org/10.22028/D291-41062Test https://doi.org/10.1038/leu.2017.121Test http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-410627Test |
| حقوق: | openAccess ; CC BY-NC-SA 4.0 Deed Attribution-NonCommercial-ShareAlike 4.0 International ; https://creativecommons.org/licenses/by-nc-sa/4.0Test/ |
| رقم الانضمام: | edsbas.F15D500D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14765551 08876924 |
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| DOI: | 10.22028/D291-41062 |