دورية أكاديمية
T helper cell subsets and related target cells in acute COVID-19 ; Т-хелперы и их клетки-мишени при COVID-19
| العنوان: | T helper cell subsets and related target cells in acute COVID-19 ; Т-хелперы и их клетки-мишени при COVID-19 |
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| المؤلفون: | Kudryavtsev I.V., Golovkin A.S., Totolian A.A. |
| المساهمون: | 0, Работа выполнена в рамках государственного задания № 075-01135-22-00, Работа выполнена в рамках государственного задания № 075-01135-22-00. |
| المصدر: | Russian Journal of Infection and Immunity; Vol 12, No 3 (2022); 409-426 ; Инфекция и иммунитет; Vol 12, No 3 (2022); 409-426 ; 2313-7398 ; 2220-7619 |
| بيانات النشر: | SPb RAACI |
| سنة النشر: | 2022 |
| المجموعة: | Russian Journal of Infection and Immunity (Infektsiya i immunitet) / Инфекция и иммунитет |
| مصطلحات موضوعية: | COVID-19, CD4+ T-cells, Th17 cell subsets, follicular Th cell, Th1, Th2, Т-хелперы, субпопуляции Т-хелперов 17, фолликулярные Т-хелперы, Т-хелперы 1, Т-хелперы 2 |
| الوصف: | Current review presents a brief overview of the immune system dysregulation during acute COVID-19 and illustrates the main alterations in peripheral blood CD4+ T-cell (Th) subsets as well as related target cells. Effects of dendritic cell dysfunction induced by SARS-CoV-2 exhibited decreased expression of cell-surface HLA-DR, CCR7 as well as co-stimulatory molecules CD80 and CD86, suggesting reduced antigen presentation, migratory and activation capacities of peripheral blood dendritic cells. SARS-CoV-2-specific Th cells could be detected as early as days 24 post-symptom onset, whereas the prolonged lack of SARS-CoV-2-specific Th cells was associated with severe and/or poor COVID-19 outcome. Firstly, in acute COVID-19 the frequency of Th1 cell was comparable with control levels, but several studies have reported about upregulated inhibitory immune checkpoint receptors and exhaustion-associated molecules (TIM3, PD-1, BTLA, TIGIT etc.) on circulating CD8+ T-cells and NK-cells, whereas the macrophage count was increased in bronchoalveolar lavage (BAL) samples. Next, type 2 immune responses are mediated mainly by Th2 cells, and several studies have revealed a skewing towards dominance of Th2 cell subset in peripheral blood samples from patients with acute COVID-19. Furthermore, the decrease of circulating main Th2 target cells basophiles and eosinophils were associated with severe COVID-19, whereas the lung tissue was enriched with mast cells and relevant mediators released during degranulation. Moreover, the frequency of peripheral blood Th17 cells was closely linked to COVID-19 severity, so that low level of Th17 cells was observed in patients with severe COVID-19, but in BAL the relative number of Th17 cells as well as the concentrations of relevant effector cytokines were dramatically increased. It was shown that severe COVID-19 patients vs. healthy control had higher relative numbers of neutrophils if compared, and the majority of patients with COVID-19 had increased frequency and absolute number of immature ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
| العلاقة: | https://iimmun.ru/iimm/article/view/1882/1414Test; https://iimmun.ru/iimm/article/view/1882/1506Test; https://iimmun.ru/iimm/article/downloadSuppFile/1882/7665Test; https://iimmun.ru/iimm/article/downloadSuppFile/1882/7666Test; https://iimmun.ru/iimm/article/downloadSuppFile/1882/7667Test; https://iimmun.ru/iimm/article/downloadSuppFile/1882/7668Test; https://iimmun.ru/iimm/article/downloadSuppFile/1882/7669Test; https://iimmun.ru/iimm/article/downloadSuppFile/1882/7670Test; https://iimmun.ru/iimm/article/downloadSuppFile/1882/7671Test; https://iimmun.ru/iimm/article/downloadSuppFile/1882/7728Test; https://iimmun.ru/iimm/article/view/1882Test |
| DOI: | 10.15789/2220-7619-THC-1882 |
| الإتاحة: | https://doi.org/10.15789/2220-7619-THC-1882Test https://iimmun.ru/iimm/article/view/1882Test |
| حقوق: | Copyright (c) 2022 Kudryavtsev I.V., Golovkin A.S., Totolian A.A. ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.88846747 |
| قاعدة البيانات: | BASE |
| DOI: | 10.15789/2220-7619-THC-1882 |
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