التفاصيل البيبلوغرافية
| العنوان: |
Урогенитальная хламидийная инфекция. Бактериальная нагрузка возбудителя и особенности клинического течения инфекции |
| المؤلفون: |
Негашева Е.С., Потекаев Н.Н., Фриго Н.В., Гущин А.Е., Сенина М.Е., Доля О.В., Полевщикова С.А. |
| المصدر: |
Клиническая дерматология и венерология |
| بيانات النشر: |
Общество с ограниченной ответственностью Издательство Медиа Сфера |
| المجموعة: |
RUDN University Open Repository (RUOR) |
| مصطلحات موضوعية: |
C.trachomatis, bacterial load, chlamydia infection, clinical course, бактериальная нагрузка, хламидиоз, клиническое течение |
| الوصف: |
Background. Infection caused by C. trachomatis is the most common bacterial sexually transmitted infection worldwide. However, the bacterial load of the causative agent is often not taken into account in clinical features of the disease assessment and therapy administration. Objective. To study bacterial load in patients with uncomplicated urogenital chlamydia infection and its correlation with the type of the disease clinical course. Material and methods. The study subject is 497 patients with uncomplicated urogenital chlamydia infection, including 398 men and 99 women, who were under the medical supervision in MSPCDC (Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology) in 2021. The research material is scrapes/discharge from the mucous membrane of urogenital tract organs of patients. The research method is real-time PCR with determination of C. trachomatis bacterial load. Bacterial load was considered relatively low at C. trachomatis DNA concentration of 104 GE/ml and less, relatively high at C. trachomatis DNA concentration more than 104 GE/ml. Results. Patients with low bacterial load of C. trachomatis (62.8%), both in men (60.3%) and women (72.8%), prevailed among patients with urogenital chlamydia infection. There is a significant direct correlation between bacterial load’s rate of C. trachomatis and presence of disease clinical signs (dysuria, excretion from the reproductive tract, etc.) among male patients (ξ2 =42.39; OR 7.34; p<0.001) and in the general group of patients, where men dominated (ξ2=28.93; OR 4.97; p<0.001). Comparable correlation among women wasn’t revealed. Conclusion. The bacterial load of C. trachomatis in the urogenital tract of patients may affect the chlamydia clinical course in male subjects. Women with either low or especially high bacterial load and asymptomatic disease course are reservoirs of infection and contribute to its spread. ; Актуальность. Инфекция, вызываемая C. trachomatis, - наиболее распространенная бактериальная инфекция, передаваемая ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
Russian |
| العلاقة: |
https://repository.rudn.ru/records/article/record/102851Test/ |
| الإتاحة: |
https://repository.rudn.ru/records/article/record/102851Test/ |
| رقم الانضمام: |
edsbas.FEDC6F33 |
| قاعدة البيانات: |
BASE |
