دورية أكاديمية
Defining the toxicity of current regimens for extranodal NK/T cell lymphoma: a systematic review and metaproportion
| العنوان: | Defining the toxicity of current regimens for extranodal NK/T cell lymphoma: a systematic review and metaproportion |
|---|---|
| المؤلفون: | Pokrovsky V.S., Vinnikov D. |
| المصدر: | Expert Review of Anticancer Therapy |
| بيانات النشر: | Taylor and Francis Ltd |
| المجموعة: | RUDN University Open Repository (RUOR) |
| مصطلحات موضوعية: | Extra-nodal NK/T cell lymphoma, L-asparaginase-based regimens, systematic review, tolerability, toxicity |
| الوصف: | Objectives: The aim of this study is to compare the toxicity profiles of SMILE versus less intense L-asparaginase-containing regimens, CCRT or “sandwich” RT+CT regimens. Methods: PRISMA protocol was used to search Pubmed and Embase for studies of treatment regimens for extranodal NK/T-cell lymphoma, nasal type (ENKTL) in English published before March 2018. Pooled data were grouped into five categories: A) CHOP-like regimens; B) Gemcitabine-based regimens; C) SMILE-like regimens; D) Concurrent and “sandwich” RT + CT; and E) Methotrexate-based combinations. We pooled prevalence of selected adverse events from each study to calculate the weighted overall prevalence using meta-proportion in Stata. Results: Group C was the most toxic with the pooled neutropenia 72% (95 CI 64;80) and thrombocytopenia 48% (95% CI 40;55) prevalence. The use of Group D treatment regimens was associated with the lowest anemia (10% (95% CI 1;19)) prevalence. Group E was the least toxic with regard to thrombocytopenia (6% (95% CI 1;11). Conclusion: Our analysis confirms that SMILE regimen, which is current standard to treat advanced-stage ENKTL may be associated with more severe hematological toxicity compared to other L-asparaginase combinations, including methotrexate-based (AspaMetDex, MESA and MEDA) or gemcitabine-based (GELOX, PGEMOX, DDGP, GDL, GOLD, GLIDE) or CCRT-based regimens. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1080/14737140.2019.1549992Test; https://repository.rudn.ru/records/article/record/36099Test/ |
| الإتاحة: | https://doi.org/10.1080/14737140.2019.1549992Test https://repository.rudn.ru/records/article/record/36099Test/ |
| رقم الانضمام: | edsbas.4B9C9037 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |