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1دورية أكاديمية
المؤلفون: Mizanbekov S.K., Zhapparkulova K.N., Tattimbetova Z.H.O., Joldasbekova B.U., Alexandrova O.I.
المصدر: Известия высших учебных заведений. Технология текстильной промышленности
مصطلحات موضوعية: Educational appli-cations, Electronic linguodidactics, Information technology competence, Moodle, Platforms, univer
الوصف: The article is devoted to the theory and practice of the use of electronic educational resources. The main attention is paid to the conditions, methods and forms of integrating digital technologies into the educational processf which are focused on the formation of key competencies of students. The purpose of the study is to consider the potential possibilities of the object-oriented dynamic learning environment Moodle and the methodological foundations for using the electronic learning format "Univer". The authors analyzed the technical and psychological readiness of students to use the electronic training format It is concluded that most modern students are technically and psychologically ready to use electronic educational resources and it is necessary to consider new opportunities for more efficient use of the potential of intelligent technologies. © 2019 Ivanovo State Polytechnic University. All rights reserved.
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2دورية أكاديمية
المؤلفون: Kobzev M.S., Titov A.A., Alexandrova E.V., Purgatorio R., Catto M., Sorokina E.A., Borisova T.N., Varlamov A.V., Altomare C.D., Voskressensky L.G.
المصدر: MOLECULAR DIVERSITY
مصطلحات موضوعية: Acetylcholinesterase inhibitors, Azacyclic allenes, N-bridged cyclopenta[a]indenes
الوصف: Various 4′-R-substituted phenyl azacyclic allenes were synthesized in good yields, and their thermal transformations were studied. For the first time, the obtained rearrangement products—new N-bridged cyclopenta[a]indenes, and the corresponding parent allenes were evaluated as potential inhibitors of acetyl- and butyrylcholinesterase. Among the tested compounds, the allene derivative 2g proved to competitively inhibit human AChE with inhibition constant value (Ki) in the low micromolar range. Graphic abstract: [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG part of Springer Nature.
العلاقة: https://doi.org/10.1007/s11030-021-10185-8Test; https://repository.rudn.ru/records/article/record/72349Test/
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3دورية أكاديمية
المؤلفون: Popova S.V., Karandeyeva L.G., Alexandrova A.A.
المصدر: Актуальные проблемы образования и воспитания: интеграция теории и практики
مصطلحات موضوعية: organizational and pedagogical conditions, pedagogical task, education system, организационно-педагогические условия, педагогическая задача, система воспитания
الوصف: In the paper organizational and pedagogical conditions are defined as a system of forms, methods, material conditions, as well as real situations that arose for objective or subjective reasons to solve complex pedagogical problems. The main organizational and pedagogical conditions include the following: improving the managerial culture of the head of the educational organization, developing a self-government system in the school, humanizing the educational process and enriching the experience of humane relations of students, the formation of tolerant relations, interaction (cooperation) of teachers, students and parents in the process training and education, the formation of spiritual and value orientations of modern schoolchildren. ; В данной статье организационно-педагогические условия определяются как система форм, методов, материальных условий, а также реальных ситуаций, возникших по объективной или субъективной причине для решения комплексных педагогических задач. К основным организационно-педагогическим условиям относятся следующие: повышение уровня управленческой культуры руководителя образовательной организации, развитие в школе системы самоуправления, гуманизация учебно-воспитательного процесса и обогащение опыта гуманного отношения школьников, формирование толерантных отношений, взаимодействие (сотрудничество) учителей, учеников и родителей в процессе обучения и воспитания, формирование духовно-ценностных ориентиров современных школьников.
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4دورية أكاديمية
المؤلفون: Sergeeva M.G., Alexandrova E.A., Mukhin M.I., Oreshkina A.K., Lukashenko D.V.
المصدر: Revista Inclusiones
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5دورية أكاديمية
المؤلفون: Crous P.W., Wingfield M.J., Lombard L., Roets F., Swart W.J., Alvarado P., Carnegie A.J., Moreno G., Luangsa-Ard J., Thangavel R., Alexandrova A.V., Baseia I.G., Bellanger J.-M., Bessette A.E., Bessette A.R., García D., Gené J., Pham T.H.G., Heykoop M., Malysheva E., Malysheva V., Martín M.P., Morozova O.V., Noisripoom W., Overton B.E., Rea A.E., Sewall B.J., Smith M.E., Smyth C.W., Tasanathai K., Visagie C.M., Adamčík S., Alves A., Andrade J.P., Aninat M.J., Araújo R.V.B., Bordallo J.J., Boufleur T., Baroncelli R., Barreto R.W., Bolin J., Cabero J., Caboň M., Cafà G., Caffot M.L.H., Cai L., Carlavilla J.R., Chávez R., Delgat L., Deschuyteneer D., Dios M.M., Domínguez L.S., Evans H.C., Eyssartier G., Ferreira B.W., Figueiredo C.N., Liu F., Fournier J., Galli-Terasawa L.V., Gil-Durán C., Glienke C., Gonçalves M.F.M., Gryta H., Guarro J., Himaman W., Hywel-Jones N., Iturrieta-González I., Ivanushkina N.E., Jargeat P., Khalid A.N., Khan J., Kiran M., Kiss L., Kochkina G.A., Kolařík M., Kubátová A., Lodge D.J., Loizides M., Luque D., Manjón J.L., Marbach P.A.S., Mata M., Miller A.N., Mongkolsamrit S., Moreau P.-A., Morte A., Mujic A., Navarro-Ródenas A., Németh M.Z., Nóbrega T.F., Nováková A., Olariaga I., Ozerskaya S.M., Palma M.A., Petters-Vandresen D.A.L., Piontelli E., Popov E.S., Rodríguez A., Requejo Ó., Rodrigues A.C.M., Rong I.H., Roux J., Seifert K.A., Silva B.D.B., Sklenář F., Smith J.A., Sousa J.O., Souza H.G., Švec K., Tanchaud P., Tanney J.B., Terasawa F., Thanakitpipattana D., Torres-Garcia D., Vaca I., Vaghefi N., Vasilenko O.V., Verbeken A., Yilmaz N., Zamora J.C., Zapata M., Jurjević Ž., Groenewald J.Z., De La Peña-Lastra S., De Castro R.R.L., Massola N.S.Jr., De Souza J.T., Van Iperen A.L.
المصدر: Persoonia: Molecular Phylogeny and Evolution of Fungi
مصطلحات موضوعية: ITS nrDNA barcodes, LSU, New taxa, Systematics
الوصف: Novel species of fungi described in this study include those from various countries as follows: Antarctica, Apenidiella antarctica from permafrost, Cladosporium fildesense from an unidentified marine sponge. Argentina, Geastrum wrightii on humus in mixed forest. Australia, Golovinomyces glandulariae on Glandularia aristigera, Neoanungitea eucalyptorum on leaves of Eucalyptus grandis, Teratosphaeria corymbiicola on leaves of Corymbia ficifolia, Xylaria eucalypti on leaves of Eucalyptus radiata. Brazil, Bovista psammophila on soil, Fusarium awaxy on rotten stalks of Zea mays, Geastrum lanuginosum on leaf litter covered soil, Hermetothecium mikaniae-micranthae (incl. Hermetothecium gen. nov.) on Mikania micrantha, Penicillium reconvexovelosoi in soil, Stagonosporopsis van-naccii from pod of Glycine max. British Virgin Isles, Lactifluus guanensis on soil. Canada, Sorocybe oblongispora on resin of Picea rubens. Chile, Colletotrichum roseum on leaves of Lapageria rosea. China, Setophoma caverna from carbonatite in Karst cave. Colombia, Lareunionomyces eucalypticola on leaves of Eucalyptus grandis. Costa Rica, Psathyrella pivae on wood. Cyprus, Clavulina iris on calcareous substrate. France, Chromosera ambigua and Clavulina iris var. occidentalis on soil. French West Indies, Helminthosphaeria hispidissima on dead wood. Guatemala, Talaromyces guatemalensis in soil. Malaysia, Neotracylla pini (incl. Tracyllales ord. nov. and Neotracylla gen. nov.) and Vermiculariopsiella pini on needles of Pinus tecunumanii. New Zealand, Neoconiothyrium viticola on stems of Vitis vinifera, Parafenestella pittospori on Pittosporum tenuifolium, Pilidium novae-zelandiae on Phoenix sp. Pakistan, Russula quercus-floribundae on forest floor. Portugal, Trichoderma aestuarinum from saline water. Russia, Pluteus liliputianus on fallen branch of deciduous tree, Pluteus spurius on decaying deciduous wood or soil. South Africa, Alloconiothyrium encephalarti, Phyllosticta encephalarticola and Neothyrostroma encephalarti (incl. Neothyrostroma gen. ...
العلاقة: https://doi.org/10.3767/persoonia.2019.43.06Test; https://repository.rudn.ru/records/article/record/65709Test/
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6دورية أكاديمية
المؤلفون: Novozhilov Y.K., Shchepin O.N., Schnittler M., Dagamac N.H.A., Alexandrova A.V., Popov E.S., Kuznetsov A.N.
المصدر: Nova Hedwigia
مصطلحات موضوعية: Amoebozoa, Biodiversity, Ecology, Elevation gradient, Myxogastria, Slime moulds, Southeast Asia, Species inventory, Species richness, Substrate effects
الوصف: A systematic survey for myxomycetes was carried out in 2011–2014 and 2017 at 106 localities in mountain tropical forests of Bidoup Nui Ba and Chu Yang Sin national parks (Dalat Plateau, southern Vietnam). In total, the survey yielded 652 records, of which 358 were field collections and 294 were collections obtained from 819 moist chamber cultures prepared with samples taken from the bark surface of living trees, ground and aerial litter and coarse woody debris. Determinations resulted in 105 taxa from 28 genera and 10 families. More than half (61) of all taxa were classified as rare. One collection of Badhamia could not be clearly assigned to any described species. Forty-two taxa were recorded for the first time for Vietnam and all were new for both national parks. The number of recorded taxa, increasing in a near-linear fashion with the number of field seasons, since sporulation activity of different species varies from year to year. Among the four natural vegetation types: middle mountain polydominant (A), mixed broadleaf-coniferous (B), middle mountain open pyrogenic coniferous (C), and high mountain cloud forest (D), completeness of the survey was highest for the first one. A pattern of decreasing diversity with increasing eleva-tion was found. In contrast, the specificity of myxomycete assemblages increased progressively in the sequence of vegetation types from A to D. In addition, artificial banana plantations (E) comprised the most distinctive but as well the least diverse myxomycete assemblage among all studied vegetation types. The taxonomic composition of myxomycete assemblages on major substrate groups differs from that in lowland forests, and species diversity increased from bark and aerial litter to ground litter and wood. © 2019 J. Cramer in Gebrüder Borntraeger Verlagsbuchhandlung, Stuttgart, Germany.
العلاقة: https://doi.org/10.1127/nova_hedwigia/2019/0560Test; https://repository.rudn.ru/records/article/record/64982Test/
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7دورية أكاديمية
المؤلفون: Zhdanov D.D., Plyasova A.A., Pokrovsky V.S., Pokrovskaya M.V., Alexandrova S.S., Gladilina Y.A., Sokolov N.N.
المصدر: Biochimie
مصطلحات موضوعية: Alternative splicing, Apoptosis progression, Deoxyribonuclease I, Lymphocytes, Splice-switching oligonucleotide
الوصف: The nuclease activity of deoxyribonuclease 1 (DNase I) is regulated by alternative splicing (AS) of its mRNA. The aim of this study was to define the ability of a splice-switching oligonucleotide (SSO) that base-paired with DNase I pre-mRNA to induce AS and inhibit nuclease activity in human T, B and NK lymphocytes. The SSO for DNase I could significantly downregulate the expression of full-length active DNase I and upregulate a truncated splice variant with a deleted exon 4. Such an induction of AS resulted in inhibition of nuclease activity and slowed apoptosis progression in anti-CD95/FAS stimulated lymphocytes. These results should facilitate further investigations of apoptosis regulation in lymphocytes and demonstrate that SSOs for DNase I are promising cytoprotective agents. © 2020 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)
العلاقة: https://doi.org/10.1016/j.biochi.2020.04.009Test; https://repository.rudn.ru/records/article/record/64583Test/
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8دورية أكاديمية
المؤلفون: Plyasova A.A., Pokrovskaya M.V., Lisitsyna O.M., Pokrovsky V.S., Alexandrova S.S., Hilal A., Sokolov N.N., Zhdanov D.D.
المصدر: Pharmaceuticals
مصطلحات موضوعية: Clathrin, Dynamin, Endocytosis, Rhodospirillum rubrum L‐asparaginase, Telomerase
الوصف: The anticancer effect of L‐asparaginases (L‐ASNases) is attributable to their ability to hydrolyze L‐asparagine in the bloodstream and cancer cell microenvironment. Rhodospirillum rubrum (RrA) has dual mechanism of action and plays a role in the suppression of telomerase activity. The aim of this work was to investigate the possible mechanism of RrA penetration into human cancer cells. Labeling of widely used L‐ASNases by fluorescein isothiocyanate followed by flow cytometry and fluorescent microscopy demonstrated that only RrA can interact with cell membranes. The screening of inhibitors of receptor‐mediated endocytosis demonstrated the involvement of clathrin receptors in RrA penetration into cells. Confocal microscopy confirmed the cytoplasmic and nuclear localization of RrA in human breast cancer SKBR3 cells. Two predicted nuclear localization motifs allow RrA to penetrate into the cell nucleus and inhibit telomerase. Chromatin relaxation promoted by different agents can increase the ability of RrA to suppress the expression of telomerase main catalytic subunit. Our study demonstrated for the first time the ability of RrA to penetrate into human cancer cells and the involvement of clathrin receptors in this process. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
العلاقة: https://doi.org/10.3390/ph13100286Test; https://repository.rudn.ru/records/article/record/64360Test/
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9دورية أكاديمية
المؤلفون: Alexandrova O.I.
المصدر: Вестник Российского университета дружбы народов. Серия: Теория языка. Семиотика. Семантика
مصطلحات موضوعية: заимствование, исконная лексика, многозначность, моносемия, семантизация, вторичная семантическая функция, loanwords, borrowings, original native lexis, polysemy, monosemy, semantization, secondary semantic function
الوصف: Language lexical system is the most vulnerable for loanwords as this is the regular means to enlarge vocabulary. Getting into a new language environment, a loanword used to be adopted by all possible means - from phonetics to syntax - and inevitably obtains a number of new meanings. Thus it makes a full-featured language unit. ; Лексическая система является наиболее проницаемой для заимствований, поскольку таким образом пополняется словарь языка. Попадая в новую языковую среду, заимствованное слово начитает осваиваться всеми возможными средствами - от фонетики до синтаксиса - и неизбежно обрастает новыми значениями. Таким образом, оно становится полноценным элементом языка.
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10دورية أكاديمية
المؤلفون: Plyasova A.A., Berrino E., Khan I.I., Veselovsky A.V., Pokrovsky V.S., Angeli A., Ferraroni M., Supuran C.T., Pokrovskaya M.V., Alexandrova S.S., Gladilina Y.A., Sokolov N.N., Hilal A., Carta F., Zhdanov D.D.
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: antineoplastic agent, carbonate dehydratase, enzyme inhibitor, sulfonamide, telomerase, zidovudine, animal, Bagg albino mouse, cell proliferation, chemical structure, chemistry, dose response, drug effect, drug screening, experimental neoplasm, female, human, metabolism, mouse, nude mouse, pathology, structure activity relation, synthesis, tumor cell culture, Animals, Antineoplastic Agents, Carbonic Anhydrases, Dose-Response Relationship, Drug, Drug Screening Assays
الوصف: Human (h) telomerase (TL; EC 2.7.7.49) plays a key role in sustaining cancer cells by means of elongating telomeric repeats at the 3′ ends of chromosomes. Since TL-inhibitor (TI) stand-alone cancer therapy has been proven to be remarkably challenging, a polypharmacological approach represents a valid alternative. Here we consider a series of compounds able to inhibit both hTL and the tumor-associated carbonic anhydrases (CAs; EC 4.2.1.1) IX and XII. Compounds 7 and 9 suppressed hTL activity in both cell lysates and human colon cancer cell lines, and prolonged incubation with either 7 or 9 resulted in telomere shortening, cell cycle arrest, replicative senescence, and apoptosis. Enzyme kinetics showed that 7 and 9 are mixed-type inhibitors of the binding of DNA primers and deoxynucleoside triphosphate (dNTP) to the TL catalytic subunit hTERT, which is in agreement with docking experiments. Compound 9 showed antitumor activity in Colo-205 mouse xenografts and suppressed telomerase activity by telomere reduction. © 2021 American Chemical Society.
العلاقة: https://doi.org/10.1021/acs.jmedchem.1c00756Test; https://repository.rudn.ru/records/article/record/76700Test/
