دورية أكاديمية
Space and Genotype-Dependent Virus Distribution during Infection Progression
| العنوان: | Space and Genotype-Dependent Virus Distribution during Infection Progression |
|---|---|
| المؤلفون: | Bessonov N., Bocharov G., Volpert V. |
| المصدر: | Mathematics |
| بيانات النشر: | MDPI AG |
| المجموعة: | RUDN University Open Repository (RUOR) |
| مصطلحات موضوعية: | Genotype, Infection progression, Nonlocal interaction, Virus density distribution, Wave propagation |
| الوصف: | The paper is devoted to a nonlocal reaction-diffusion equation describing the development of viral infection in tissue, taking into account virus distribution in the space of genotypes, the antiviral immune response, and natural genotype-dependent virus death. It is shown that infection propagates as a reaction-diffusion wave. In some particular cases, the 2D problem can be reduced to a 1D problem by separation of variables, allowing for proof of wave existence and stability. In general, this reduction provides an approximation of the 2D problem by a 1D problem. The analysis of the reduced problem allows us to determine how viral load and virulence depend on genotype distribution, the strength of the immune response, and the level of immunity. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/math10010096Test; https://repository.rudn.ru/records/article/record/84320Test/ |
| الإتاحة: | https://doi.org/10.3390/math10010096Test https://repository.rudn.ru/records/article/record/84320Test/ |
| رقم الانضمام: | edsbas.E2BB69B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |