دورية أكاديمية
A randomized, placebo-controlled study of the effects of telcagepant on exercise time in patients with stable angina
| العنوان: | A randomized, placebo-controlled study of the effects of telcagepant on exercise time in patients with stable angina |
|---|---|
| المؤلفون: | Chaitman B.R., Ho A.P., Behm M.O., Rowe J.F., Palcza J.S., Laethem T., Heirman I., Panebianco D.L., Kobalava Z., Martsevich S.Y., Free A.L., Bittar N., Chrysant S.G., Ho T.W., Chodakewitz J.A., Murphy M.G., Blanchard R.L. |
| المصدر: | Clinical Pharmacology and Therapeutics |
| المجموعة: | RUDN University Open Repository (RUOR) |
| مصطلحات موضوعية: | placebo, telcagepant, adult, aged, article, confidence interval, controlled study, crossover procedure, double blind procedure, female, flushing, headache, heart rate, heart ventricle extrasystole, human, major clinical study, male, phase 1 clinical trial, priority journal, randomized controlled trial, side effect, stable angina pectoris, time, time to maximum plasma concentration, treadmill exercise time, Angina, Stable, Azepines, Cross-Over Studies, Double-Blind Method |
| الوصف: | Telcagepant is a calcitonin gene-related peptide (CGRP) receptor antagonist being evaluated for acute migraine treatment. CGRP is a potent vasodilator that is elevated after myocardial infarction, and it delays ischemia during treadmill exercise. We tested the hypothesis that CGRP receptor antagonism does not reduce treadmill exercise time (TET). The effects of supratherapeutic doses of telcagepant on TET were assessed in a double-blind, randomized, placebo-controlled, two-period, crossover study in patients with stable angina and reproducible exercise-induced angina. Patients received telcagepant (600 mg, n = 46; and 900 mg, n = 14) or placebo and performed treadmill exercise at T max (2.5 h after the dose). The hypothesis that telcagepant does not reduce TET was supported if the lower bound of the two-sided 90% confidence interval (CI) for the mean treatment difference (telcagepant-placebo) in TET was more than 60 s. There were no significant between-treatment differences in TET (mean treatment difference: 6.90 (90% CI: 17.66, 3.86) seconds), maximum exercise heart rate, or time to 1-mm ST-segment depression using pooled data or with stratification for dose. © 2012 american Society for clinical Pharmacology and Therapeutics. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1038/clpt.2011.246Test; https://repository.rudn.ru/records/article/record/2352Test/ |
| الإتاحة: | https://doi.org/10.1038/clpt.2011.246Test https://repository.rudn.ru/records/article/record/2352Test/ |
| رقم الانضمام: | edsbas.C3FC8879 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |