دورية أكاديمية
Profiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification
| العنوان: | Profiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification |
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| المؤلفون: | Reyes Palomares, Arturo Lazaro, Ruiz-Galdón, Maximiliano, Liu, Kui, Reyes-Engel, Armando, Rodriguez-Wallberg, Kenny A. |
| بيانات النشر: | IOAP-MPDI |
| سنة النشر: | 2022 |
| المجموعة: | RIUMA - Repositorio Institucional de la Universidad de Málaga |
| مصطلحات موضوعية: | Embarazo, Carbono, One-carbon metabolism, IVF, ART, Embryo viability, Folic acid, MTHFR, ABCB1, BHMT, SHMT1, Gene polymorphism, Oocyte donation |
| الوصف: | Partial funding for open access charge: Universidad de Málaga ; Nutritional status and gene polymorphisms of one-carbon metabolism confer a well-known interaction that in pregnant women may affect embryo viability and the health of the newborn. Folate metabolism directly impacts nucleotide synthesis and methylation, which is of increasing interest in the reproductive medicine field. Studies assessing the genetic influence of folate metabolism on IVF treatments have currently been performed in women using their own oocytes. Most of these patients seeking to have a child or undergoing IVF treatments are advised to preventively intake folate supplies that restore known metabolic imbalances, but the treatments could lead to the promotion of specific enzymes in specific women, depending on their genetic variance. In the present study, we assess the influence of candidate gene variants related to folate metabolism, such as Serine Hydroxymethyltransferase 1 SHMT1 (rs1979276 and rs1979277), Betaine-Homocysteine S-Methyltransferase BHMT (rs3733890), Methionine synthase reductase MTRR (rs1801394), Methylenetetrahydrofolate reductase MTHFR (rs1801131 and rs1801133), methionine synthase MTR (rs12749581), ATP Binding Cassette Subfamily B Member 1 ABCB1 (rs1045642) and folate receptor alpha FOLR1 (rs2071010) on the success of IVF treatment performed in women being recipients of donated oocytes. The implication of such gene variants seems to have no direct impact on pregnancy consecution after IVF; however, several gene variants could influence pregnancy loss events or pregnancy maintenance, as consequence of folic acid fortification. ; This research was funded by grant PTQ 09–01-00496, Ministerio de Economía y Competitividad (MINECO), Government of Spain, Instituto de Fertilidad Clínica Rincón y Fundación Rincón. AR Palomares and KA Rodriguez-Wallberg are supported by grants from the Swedish Research Council (VR Dnr 2021-06116, Dnr 2020–02230), the Swedish Cancer Society (CAN 2017/704, 20 0170 F) and Karolinska Institutet ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Palomares, A.R.; Ruiz-Galdon, M.; Liu, K.; Reyes-Engel, A.; Rodriguez-Wallberg, K.A. Profiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification. Int. J. Mol. Sci. 2022, 23, 11298. https://doi.org/10.3390/ijms231911298Test; https://hdl.handle.net/10630/25805Test; https://doi.org/10.3390/ijms231911298Test |
| DOI: | 10.3390/ijms231911298 |
| الإتاحة: | https://doi.org/10.3390/ijms231911298Test https://hdl.handle.net/10630/25805Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ ; Atribución 4.0 Internacional |
| رقم الانضمام: | edsbas.3BFE4982 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms231911298 |
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