دورية أكاديمية
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
| العنوان: | Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease |
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| المؤلفون: | Bettinetti-Luque, Miriam, Trujillo-Estrada, Laura Isabel, García-Fuentes, Eduardo, Andreo-López, Juana, Sánchez-Varo, Raquel María, Gómez-Mediavilla, Ángela, López, Manuela G., Gutiérrez, Antonia, Baglietto-Vargas, David, Garrido-Sánchez, Lourdes, García-Caballero, Melissa |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | RIUMA - Repositorio Institucional de la Universidad de Málaga |
| مصطلحات موضوعية: | Tejido adiposo, Alzheimer, Enfermedad de, Amiloide, Inflamación (Patología), Sistema cardiovascular - Enfermedades, Adipokines, Adipose tissue, Alzheimer's disease, Amyloid, Inflammation, Tau, Vascular |
| الوصف: | Adipose tissue has recently been recognized as an important endocrine organ that plays a crucial role in energy metabolism and in the immune response in many metabolic tissues. With this regard, emerging evidence indicates that an important crosstalk exists between the adipose tissue and the brain. However, the contribution of adipose tissue to the development of age-related diseases, including Alzheimer's disease, remains poorly defined. New studies suggest that the adipose tissue modulates brain function through a range of endogenous biologically active factors known as adipokines, which can cross the blood–brain barrier to reach the target areas in the brain or to regulate the function of the blood–brain barrier. In this review, we discuss the effects of several adipokines on the physiology of the blood–brain barrier, their contribution to the development of Alzheimer's disease and their therapeutic potential. ; Funding for open access charge; Universidad de Málaga / CBUA Funding information Ministry of Science and Innovation,Grant / Award Numbers:PDC2022-133809-I00, PID2021-125986OB-I00, PID2019-108911RA-100; Alzheimer's |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Bettinetti-Luque, M., Trujillo-Estrada, L., Garcia-Fuentes, E., Andreo-Lopez, J., Sanchez-Varo, R., Garrido-Sánchez, L., Gómez-Mediavilla, Á., López, M. G., Garcia-Caballero, M., Gutierrez, A., & Baglietto-Vargas, D. (2023). Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease. British Journal of Pharmacology, 1–39. https://doi.org/10.1111/bph.16243Test; https://hdl.handle.net/10630/27854Test |
| DOI: | 10.1111/bph.16243 |
| الإتاحة: | https://doi.org/10.1111/bph.16243Test https://hdl.handle.net/10630/27854Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
| رقم الانضمام: | edsbas.9B8745DA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/bph.16243 |
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