دورية أكاديمية
Primary Cutaneous Leiomyosarcoma Arising in a Patient With Li-Fraumeni Syndrome: A Neoplasm With Unusual Histopathologic Features and Loss of Heterozygosity at TP53 Gene
| العنوان: | Primary Cutaneous Leiomyosarcoma Arising in a Patient With Li-Fraumeni Syndrome: A Neoplasm With Unusual Histopathologic Features and Loss of Heterozygosity at TP53 Gene |
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| المؤلفون: | Sabater Marco, Vicente, Ferrando Roca, Francisco, Morera Faet, Arturo, García García, José Ángel, Bosch, Sandra B., López Guerrero, José A. |
| المصدر: | https://journals.lww.com/amjdermatopathology/fulltext/2018/03000/primary_cutaneous_leiomyosarcoma_arising_in_a.17.aspxTest. |
| سنة النشر: | 2018 |
| المجموعة: | RIUCV - Universidad Católica de Valencia San Vicente Mártir |
| مصطلحات موضوعية: | Li-Fraumeni syndrome (LFS), Breast cancer, Cutaneous, 3201.01 Oncología |
| الوصف: | Li-Fraumeni syndrome (LFS) is an inherited cancer predisposition syndrome characterized by sarcomas in children and young adults, early-onset breast cancer, brain tumors, adrenal cortical carcinoma, and leukemia.1 In patients with this syndrome, several cutaneous neoplasias have been described such as multiple primary cutaneous melanomas,2 atypical fibrous histiocytoma,3 sebaceous carcinoma,4 infantile cutaneous rhabdomyosarcoma,5 and atypical fibroxanthoma.6 We report here the first cutaneous pilar-type leiomyosarcoma (LMS) arising in a patient with classic LFS. This tumor showed a plexiform growth pattern and similar areas to a symplastic pilar leiomyoma. Tumor analysis by Next-Generation Sequencing detected loss of heterozygosity (LOH) at TP53 gene. ; Medicina |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0193-1091 1533-0311 |
| العلاقة: | http://hdl.handle.net/20.500.12466/3409Test |
| الإتاحة: | https://doi.org/20.500.12466/3409Test https://hdl.handle.net/20.500.12466/3409Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.2D8D3E12 |
| قاعدة البيانات: | BASE |
| تدمد: | 01931091 15330311 |
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