التفاصيل البيبلوغرافية
| العنوان: |
Molecular genetics of ovarian carcinomas |
| المؤلفون: |
Diebold, Joachim |
| المصدر: |
Histology and Histopathology; Vol. 14 No. 1 (1999); 269-277 ; Histology and Histopathology; Vol. 14 Núm. 1 (1999); 269-277 ; 1699-5848 ; 0213-3911 |
| بيانات النشر: |
Histology and Histopathology |
| سنة النشر: |
2011 |
| المجموعة: |
Revistas Científicas de la Universidad de Murcia |
| مصطلحات موضوعية: |
ovarian carcinoma, molecular genetics, molecular pathology |
| الوصف: |
The phenotypic variability of epithelial ovarian neoplasms correlates with a diversity of changes at the molecular level. Invasive serous and undifferentiated ovarian carcinomas are characterized by p53 mutations with p53 protein accumulation, extensive loss of genetic material of chromosome 17 and complex changes on many other chromosomes, e.g. amplification of oncogenes. These alterations are seen only in a minority of mucinous and endometrioid carcinomas, mainly in advanced stages. Overexpression of bcl-2 is seen most frequently in endometrioid carcinomas (ca. 90% of cases), which in addition show microsatellite instability in around a third of the cases, as has been described in endometrioid endometrial carcinomas. KRAS mutations are characteristic for mucinous LMP tumors and mucinous carcinomas (40-50% of cases) and are also found in a third of serous LMP tumors. In addition, serous LMP tumors show mild microsatellite instability in 30%. However, complex chromosomal aberrations are never seen in these neoplasms. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://revistas.um.es/hh/article/view/129511/120581Test; https://revistas.um.es/hh/article/view/129511Test |
| الإتاحة: |
https://revistas.um.es/hh/article/view/129511Test |
| رقم الانضمام: |
edsbas.9BA87C23 |
| قاعدة البيانات: |
BASE |
