التفاصيل البيبلوغرافية
| العنوان: |
In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators |
| المؤلفون: |
Henrotin, Y, de Leval, X, Mathy-Hartet, M, Mouithys-Mickalad, A, Deby-Dupont, G, Dogné, J M, Delarge, J, Reginster, J Y |
| المصدر: |
Henrotin , Y , de Leval , X , Mathy-Hartet , M , Mouithys-Mickalad , A , Deby-Dupont , G , Dogné , J M , Delarge , J & Reginster , J Y 2001 , ' In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators ' , Inflammation research : official journal of the European Histamine Research Society . [et al.] , vol. 50 , no. 8 , pp. 391-9 . |
| سنة النشر: |
2001 |
| المجموعة: |
Research Portal - University of Namur / Portail de la recherche de l'Université de Namur |
| مصطلحات موضوعية: |
Adult, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Cells, Cultured, Chondrocytes, Cyclooxygenase 1, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Cytokines, DNA, Diclofenac, Dinoprostone, Humans, Inflammation Mediators, Interleukin-1, Isoenzymes, Membrane Proteins, Middle Aged, Nitric Oxide, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Prostaglandin-Endoperoxide Synthases, Reverse Transcriptase Polymerase Chain Reaction |
| الوصف: |
To investigate the mechanisms of action underlying the anti-inflammatory action of aceclofenac in vivo, we studied in vitro the effect of aceclofenac and its main metabolite, 4'-hydroxyaceclofenac, in comparison with diclofenac, another metabolite, on cyclooxygenases activity as well as interleukin-1beta, -6 and -8, nitric oxide, and prostaglandin E2 production by human osteoarthritic and normal articular chondrocytes. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
https://researchportal.unamur.be/en/publications/51b1a8a5-5cf6-421a-8315-fd74547d67ffTest |
| الإتاحة: |
https://researchportal.unamur.be/en/publications/51b1a8a5-5cf6-421a-8315-fd74547d67ffTest |
| حقوق: |
info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: |
edsbas.81066599 |
| قاعدة البيانات: |
BASE |
