التفاصيل البيبلوغرافية
| العنوان: |
Sustained improvement of negative self-schema after a single ketamine infusion: an open-label study |
| المؤلفون: |
Hasler, Gregor, Suker, Samir, Schoretsanitis, Georgios, Mihov, Yoan |
| سنة النشر: |
2020 |
| المجموعة: |
réro doc Digital Library (Library Network of Western Switzerland / Réseau des bibliothèques de Suisse occidentale) |
| الوصف: |
Conventional antidepressants have several important limitations, including a lack of direct effects on negative self-schema, which is at the core of Beck’s cognitive theory of depression. Based on previous studies showing a positive effect of ketamine on negative cognition, we compared reductions in negative self-schema between responders and non-responders to a single infusion of ketamine. In an open-label study, 26 participants with treatment-resistant depression received 0.5 mg/kg ketamine via infusion. Depression symptoms were assessed at baseline, 24 hours, and seven days after treatment with Montgomery-Ã…sberg Depression Rating Scale (MADRS) and Beck Depression Inventory (BDI-II). Nine of the 26 participants fulfilled response criteria after 24 hours. Of these, eight still fulfilled response criteria after seven days. Response was defined as a reduction in MADRS total score of 50% or more. Responders improved significantly more than non-responders both 24 hours and seven days after ketamine treatment on the following BDI-II items: item 1 (“Sadnessâ€), item 7 (“Self-Dislikeâ€), and item 8 (“Self-Criticalnessâ€). These results suggest an important therapeutic effect of ketamine on negative self-schema, which is a fundamental cognitive aspect of depression. This effect is unique and might be associated with ketamine’s profound effects on neuroplasticity. Small sample size and lack of a placebo control group are the major limitations of this study. |
| نوع الوثيقة: |
other/unknown material |
| اللغة: |
English |
| العلاقة: |
http://doc.rero.ch/record/328926/files/has_sin.pdfTest |
| الإتاحة: |
http://doc.rero.ch/record/328926/files/has_sin.pdfTest |
| رقم الانضمام: |
edsbas.C5D6E3D4 |
| قاعدة البيانات: |
BASE |
