دورية أكاديمية
Oxidative and nitrosative stress in patients with meningitis
| العنوان: | Oxidative and nitrosative stress in patients with meningitis |
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| المؤلفون: | Namiduru, Emine Siber, Namiduru, Mustafa, Karaoğlan, İlkay, Koçak, Kübra |
| بيانات النشر: | Wydawnictwo Uniwersytetu Rzeszowskiego |
| سنة النشر: | 2022 |
| المجموعة: | Repozytorium Uniwersytetu Rzeszowskiego (UR) / University of Rzeszów |
| مصطلحات موضوعية: | bacterial meningitis, oxidative stress, nitrotyrosine, tuberculous meningitis, viral menengitis |
| الوصف: | Introduction and aim. Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known as the meninges. In this study, oxidative and nitrosative stress were evaluated in cerebrospinal fluid (CSF) and blood samples that were taken from patients with meningitis. Our goal was to identify a fast and a reliable biomarker using these parameters in order to the early diagnose of bacterial meningitis. Material and methods. In this study, 37 bacterial meningitis, 30 tuberculous meningitis and 30 viral meningitis cases were included. Serum/CSF total oxidant status (TAS) and total antioxidant status (TOS) were measured by the Erel method. Nitrotyrosine concentrations were quantified by using ELISA in both serum and CSF Results. Serum nitrotyrosine, CSF TAS and TOS levels were not significantly different in three groups (p>0.05). CSF nitrotyrosine levels were significantly higher in bacterial meningitis than tuberculous meningitis group (p<0.05). Viral meningitis patients had higher serum TOS and TAS concentrations than tuberculous meningitis group (p<0.05). Conclusion. As a result, we can say that the oxidative and nitrosative stress markers studied are not a rapid and reliable biomarker in bacterial meningitis’s diagnosis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2544-1361 |
| العلاقة: | European Journal of Clinical and Experimental Medicine T. 20, z. 1 (2022), s. 70–74; http://repozytorium.ur.edu.pl/handle/item/7603Test |
| DOI: | 10.15584/ejcem.2022.1.10 |
| الإتاحة: | https://doi.org/10.15584/ejcem.2022.1.10Test http://repozytorium.ur.edu.pl/handle/item/7603Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 Międzynarodowe ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.520269AC |
| قاعدة البيانات: | BASE |
| تدمد: | 25441361 |
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| DOI: | 10.15584/ejcem.2022.1.10 |