دورية أكاديمية
Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies—Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study
| العنوان: | Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies—Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study |
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| المؤلفون: | Lekšić, Gloria, Baretić, Maja, Gudelj, Lara, Radić, Marija, Miličić, Iva, Ivanišević, Marina, Jurišić Eržen, Dubravka |
| المصدر: | https://www.mdpi.com/2227-9059/10/9/2175Test ; Biomedicines ; Volume 10 ; Issue 9 ; ISSN 2227-9059 (Online. |
| سنة النشر: | 2022 |
| المجموعة: | Repository of the University of Rijeka |
| مصطلحات موضوعية: | diabetes mellitus type 1, pregnancy, large-for-gestational-age neonates, glycemic variability, continuous glucose monitoring, J-index, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine |
| الوصف: | Pregnancies with type 1 diabetes mellitus (T1DM) have a high incidence of large-for-gestational-age neonates (LGA) despite optimal glycemic control. In recent years, glycemic variability (GV) has emerged as a possible risk factor for LGA, but the results of the conducted studies are unclear. This study analyzed the association between GV and LGA development in pregnancies with T1DM. This was a prospective cohort study of patients with T1DM who used continuous glucose monitoring (CGM) during pregnancy. Patients were followed from the first trimester to birth. GV parameters were calculated for every trimester using the EasyGV calculator. The main outcomes were LGA or no-LGA. Logistic regression analysis was used to assess the association between GV parameters and LGA. In total, 66 patients were included. The incidence of LGA was 36%. The analysis extracted several GV parameters that were significantly associated with the risk of LGA. The J-index was the only significant parameter in every trimester of pregnancy (odds ratios with confidence intervals were 1.33 (1.02, 1.73), 3.18 (1.12, 9.07), and 1.37 (1.03, 1.82), respectively. Increased GV is a risk factor for development of LGA. The J-index is a possible novel GV parameter that may be assessed in all three trimesters of pregnancy together with glycated hemoglobin and time-in-range. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Sveučilište u Rijeci. Medicinski fakultet. Katedra za internu medicinu.; University of Rijeka. Faculty of Medicine. Department of Internal Medicine.; https://www.unirepository.svkri.uniri.hr/islandora/object/medri:6765Test; https://urn.nsk.hr/urn:nbn:hr:184:337509Test; https://www.unirepository.svkri.uniri.hr/islandora/object/medri:6765/datastream/FILE0Test |
| الإتاحة: | https://doi.org/10.3390/biomedicines10092175Test https://www.unirepository.svkri.uniri.hr/islandora/object/medri:6765Test https://urn.nsk.hr/urn:nbn:hr:184:337509Test https://www.unirepository.svkri.uniri.hr/islandora/object/medri:6765/datastream/FILE0Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.D3F7C0F5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |