دورية أكاديمية
How right hemisphere damage after stroke can impair speech comprehension
| العنوان: | How right hemisphere damage after stroke can impair speech comprehension |
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| المؤلفون: | Gajardo-Vidal, Andrea, Lorca-Puls, Diego, Hope, Thomas M. H., Parker Jones, Oiwi, Seghier, Mohamed L., Prejawa, Susan, Crinion, Jennifer T., Leff, Alex P., Green, David W., Price, Cathy J. |
| سنة النشر: | 2018 |
| المجموعة: | Repositorio Universidad del Desarrollo (UDD) |
| مصطلحات موضوعية: | Right-hemisphere stroke, Lesion-deficit mapping, fMRI, Sentence comprehension, Working memory |
| الوصف: | Acquired language disorders after stroke are strongly associated with left hemisphere damage. When language difficulties are observed in the context of right hemisphere strokes, patients are usually considered to have atypical functional anatomy. By systematically integrating behavioural and lesion data from brain-damaged patients with fMRI data from neurologically-normal participants, we investigated when and why right hemisphere strokes cause language disorders. Experiment 1 studied right-handed patients with unilateral strokes that damaged the right (n = 109) or left (n = 369) hemispheres. The most frequently impaired language task was: auditory sentence-to-picture matching after right hemisphere strokes; and spoken picture description after left hemisphere strokes. For those with auditory sentence-to-picture matching impairments after right hemisphere strokes, the majority (n = 9) had normal performance on tests of perceptual (visual or auditory) and linguistic (semantic, phonological or syntactic) processing. Experiment 2 found that these nine patients, had significantly more damage to dorsal parts of the superior longitudinal fasciculus and the right inferior frontal sulcus compared to 75 other patients who also had right hemisphere strokes but were not impaired on the auditory sentence-to-picture matching task. Damage to these right hemisphere regions caused long-term speech comprehension difficulties in 67% of patients. Experiments 3 and 4, used fMRI in two groups of 25 neurologically-normal individuals to show that, within the regions identified by Experiment 2, the right inferior frontal sulcus was normally activated by (i) auditory sentence-to-picture matching and (ii) one-back matching when the demands on linguistic and non-linguistic working memory were high. Together, these experiments demonstrate that the right inferior frontal cortex contributes to linguistic and non-linguistic working memory capacity (executive function) that is needed for normal speech comprehension. Scientifically, our results ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 35 p.; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| العلاقة: | Gajardo-Vidal, Andrea, 2018, 35 p.; http://hdl.handle.net/11447/2558Test; https://doi.org/10.1093/brain/awy270Test |
| DOI: | 10.1093/brain/awy270 |
| الإتاحة: | https://doi.org/10.1093/brain/awy270Test http://hdl.handle.net/11447/2558Test |
| رقم الانضمام: | edsbas.B2FA42E5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/brain/awy270 |
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