دورية أكاديمية
Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor
| العنوان: | Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor |
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| المؤلفون: | Soza, Cristian, Bustamante, Eva, Caglevic, Christian, Rolfo, Christian, Sirera, Rafael, Marsiglia, Hugo |
| سنة النشر: | 2019 |
| المجموعة: | Repositorio Universidad del Desarrollo (UDD) |
| مصطلحات موضوعية: | Arsenic / adverse effects, Carcinogenesis / chemically induced, Carcinogenesis / pathology, Humans, Incidence, Lung Neoplasms / chemically induced, Lung Neoplasms / epidemiology, Risk Factors |
| الوصف: | Several drinkable water sources worldwide have been highly contaminated with arsenic, which means that an estimated 160 million people have been exposed to this chemical agent. If we analyse exposure by region, we will find a high correlation between arsenic contamination and the incidence of lung cancer (among other malignancies). In order to determine what the risks of these exposures are, we need to understand how this chemical is processed in our body and how it is linked to cancer. In this article we reviewed how biotransformation of ingested arsenic may lead to cancer by modulating the activation of several essential signalling pathways such as EGFR, PI3K/AKT, RTK/Ras/PI3K, JNK/STAT3 and Nrf2-KEAP1; by producing epigenetics modifications and by disrupting normal expression of miRNAs. In order to design effective health policies, educational strategies, decontaminations plans and effective medical treatments are necessary to understand the impact of arsenic pollution and the relevance of the environment in our health. ; Versión publicada |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Soza-Ried C, Bustamante E, Caglevic C, Rolfo C, Sirera R, Marsiglia H. Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor. Crit Rev Oncol Hematol. 2019 Jul;139:128-133. doi:10.1016/j.critrevonc.2019.01.012.; https://doi.org/10.1016/j.critrevonc.2019.01.012Test; http://hdl.handle.net/11447/6314Test |
| DOI: | 10.1016/j.critrevonc.2019.01.012 |
| الإتاحة: | https://doi.org/10.1016/j.critrevonc.2019.01.012Test http://hdl.handle.net/11447/6314Test |
| رقم الانضمام: | edsbas.54CF202F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.critrevonc.2019.01.012 |
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