دورية أكاديمية
Expression of substance P, calcitonin gene-related peptide and vascular endothelial growth factor in human dental pulp under different clinical stimuli ; Expresión de sustancia P, péptido relacionado con el gen de la calcitonina y factor de crecimiento endotelial vascular en pulpa dental humana bajo diferentes estímulos clínicos
| العنوان: | Expression of substance P, calcitonin gene-related peptide and vascular endothelial growth factor in human dental pulp under different clinical stimuli ; Expresión de sustancia P, péptido relacionado con el gen de la calcitonina y factor de crecimiento endotelial vascular en pulpa dental humana bajo diferentes estímulos clínicos |
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| المؤلفون: | Caviedes Bucheli, Javier, Lopez Moncayo, Luis Fernando, Muñoz Alvear, Hernan Dario, Gomez Sosa, Jose Francisco, Diaz Barrera, Luis Eduardo, Curtidor,Hernando, Muños Hugo, Roberto |
| المصدر: | Universidad de La Sabana ; Intellectum Repositorio Universidad de La Sabana |
| بيانات النشر: | BMC Oral Health |
| سنة النشر: | 2021 |
| المجموعة: | Repositorio Universidad de La Sabana |
| مصطلحات موضوعية: | Expression of substance P, Calcitonin gene-related peptide, Vascular endothelial |
| الوصف: | 8 páginas ; Background: The aim of this study was to measure the dental pulp infammatory response through neuropeptides (SP and CGRP) as a response to occlusal trauma, orthodontic movements and a combination of both, as well as the angiogenic defense mechanism through VEGF expression, which could be the initial step to mineralized tissue formation. Methods: Forty human dental pulp samples were collected from healthy frst premolars with extraction indicated due to orthodontic reasons from a sample of 20 patients. Patients were divided into four groups with 10 premolars each (1 mandibular and 1 maxillary premolar from each patient): healthy pulp control group, occlusal trauma group, moderate orthodontic forces group; and occlusal trauma plus moderate orthodontic forces group. Stimuli were applied for 24 h before tooth extraction in all experimental groups. All samples were processed, and SP, CGRP, and VEGF were measured by radioimmunoassay. The Kruskal–Wallis test was performed to assess signifcant diferences among groups and Mann–Whitney’s U post hoc pairwise comparisons were also performed. Results: The highest increase in SP, CGRP, and VEGF expressions was found in the occlusal trauma plus orthodontic forces group, followed by the moderate orthodontic forces, the occlusal trauma and the control groups, with statisti‑ cally signifcant diferences between all groups for each of the 3 peptides analyzed (Kruskal–Wallis p<0.001). All pos‑ sible pairwise post-hoc comparisons were also signifcant for each peptide analyzed (Mann–Whitney’s U p<0.001). Conclusion: SP, CGRP, and VEGF expressions signifcantly increase in human dental pulps when stimulated by occlusal trauma combined with moderate orthodontic forces, as compared with these two stimuli applied independently ; Antecedentes: El objetivo de este estudio fue medir la respuesta inflamatoria de la pulpa dental a través de neuropéptidos (SP y CGRP) como respuesta a trauma oclusal, movimientos de ortodoncia y una combinación de ambos, así como el mecanismo de ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | BMC Oral Health, 21(1), 1-8; Caviedes-Bucheli, J., Lopez-Moncayo, L. F., Muñoz-Alvear, H. D., Gomez-Sosa, J. F., Diaz-Barrera, L. E., Curtidor, H., & Munoz, H. R. (2021). Expression of substance P, calcitonin gene-related peptide and vascular endothelial growth factor in human dental pulp under different clinical stimuli. BMC Oral Health, 21(1), 1-8.; https://bmcoralhealth.biomedcentral.com/track/pdf/10.1186/s12903-021-01519-x.pdfTest; http://hdl.handle.net/10818/51117Test |
| DOI: | 10.1186/s12903-021-01519-x.pdf |
| DOI: | 10.1186/s12903-021-01519-x |
| الإتاحة: | https://doi.org/10.1186/s12903-021-01519-xTest http://hdl.handle.net/10818/51117Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.22FBE86F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12903-021-01519-x.pdf |
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