دورية أكاديمية
Use of eltrombopag for patients 65 years old or older with immune thrombocytopenia
| العنوان: | Use of eltrombopag for patients 65 years old or older with immune thrombocytopenia |
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| المؤلفون: | González López, Tomás José, Sánchez González, Blanca, Jarque, Isidro, Bernat, Silvia, Fernández Fuertes, Fernando, Caparrós, Isabel, Soto, Inmaculada, Fernández Rodríguez, Angeles, Bolaños, Estefanía, Pérez Rus, Gloria, Pascual, Cristina, Hernández Rivas, José Angel, López Ansoar, Elsa, Gómez Nuñez, Marta, Martínez Robles, Violeta, Olivera, Pavel, Yera Cobo, Maria, Peñarrubia, María Jesús, Fernández Miñano, Carmen, Cabo, Erik, Martínez Badas, María Paz, Perdomo Hernández, Germán M., García Frade, Luis Javier |
| بيانات النشر: | John Wiley & Sons |
| سنة النشر: | 2020 |
| المجموعة: | Repositorio Institucional de la Universidad de Burgos (RIUBU) |
| مصطلحات موضوعية: | elderly, eltrombopag, immune thrombocytopenia, primary, secondary, Sistema cardiovascular-Enfermedades, Cardiovascular system-Diseases |
| الوصف: | Background Eltrombopag is useful for immune thrombocytopenia (ITP). However, results of clinical trials may not accurately mirror clinical practice reality. Here we evaluated eltrombopag for primary and secondary ITP in our ≥65‐year‐old population. Methods A total of 106 primary ITP patients (16 with newly diagnosed ITP, 16 with persistent ITP, and 74 with chronic ITP) and 39 secondary ITP patients (20 with ITP secondary to immune disorders, 7 with ITP secondary to infectious diseases, and 12 with ITP secondary to lymphoproliferative disorders [LPD]) were retrospectively evaluated. Results Median age of our cohort was 76 (interquartile range, IQR, 70‐81) years. 75.9% of patients yielded a platelet response including 66.2% complete responders. Median time to platelet response was 14 (IQR, 8‐21) days. Median time on response was 320 (IQR, 147‐526) days. Sixty‐three adverse events (AEs), mainly grade 1‐2, occurred. The most common were hepatobiliary laboratory abnormalities (HBLAs) and headaches. One transient ischemic attack in a newly diagnosed ITP and two self‐limited pulmonary embolisms in secondary ITP were the only thrombotic events observed. Conclusion Eltrombopag showed efficacy and safety in ITP patients aged ≥65 years with primary and secondary ITP. However, efficacy results in LPD‐ITP were poor. A relatively high number of deaths were observed. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0902-4441 1600-0609 |
| العلاقة: | European Journal of Haematology. 2020, V. 104, n. 3, p. 259-270; https://doi.org/10.1111/ejh.13370Test; http://hdl.handle.net/10259/5243Test |
| DOI: | 10.1111/ejh.13370 |
| الإتاحة: | https://doi.org/10.1111/ejh.13370Test http://hdl.handle.net/10259/5243Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.40C92705 |
| قاعدة البيانات: | BASE |
| تدمد: | 09024441 16000609 |
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| DOI: | 10.1111/ejh.13370 |