رسالة جامعية
Influência do hipotireoidismo gestacional experimental sobre a função cardiovascular da prole de ratas ; Influence of experimental gestational hypothyroidism on cardiovascular function along the life of offspring in rats
| العنوان: | Influência do hipotireoidismo gestacional experimental sobre a função cardiovascular da prole de ratas ; Influence of experimental gestational hypothyroidism on cardiovascular function along the life of offspring in rats |
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| المؤلفون: | Santos, Sheyla Oliveira |
| المساهمون: | http://lattes.cnpq.br/3066030079712662Test, Passos Júnior, Daniel Badauê |
| بيانات النشر: | Universidade Federal de Sergipe Pós-Graduação em Ciências da Saúde BR UFS |
| سنة النشر: | 2012 |
| المجموعة: | Repositório Institucional da Universidade Federal de Sergipe (RIUFS) |
| مصطلحات موضوعية: | Hipotireoidismo gestacional, Função cardiovascular, Variabilidade da frequência cardíaca, Pressão arterial, Sistema nervoso autônomo, Dimorfismo sexual, Gestational hypothyroidism, Cardiovascular function, Heart rate variability, Blood pressure, Autonomic nervous system, Sexual dimorphism, CNPQ::CIENCIAS DA SAUDE |
| الوصف: | Gestational hypothyroidism is a prevalent disorder in pregnant women. We aimed to investigate the impact of experimental gestational hypothyroidism (EGH) on cardiovascular and autonomic nervous systems (ANS) in the offspring of rats. EGH was induced with methimazole (MMI) 0.02% in drinking water from day 9 of gestation until birth. Sixty days old offspring from MMI-treated dams (OMTD, n=13) or water-treated dams (OWTD, n=13) had femoral arteries surgically assessed for the measurements of heart rate (HR), mean (MAP), systolic (SAP) and diastolic arterial pressure (DAP), and spontaneous baroreflex sensitivity (BRS). To investigate the balance of ANS, we established the high (HF) and low frequency (LF) bands of pulse interval (PI) and LF band of SAP spectrum. OMTD had increased MAP (130.2±2.0 vs 108.8±3.0 mmHg, p < 0.001), SAP (157.3±2.9 vs 135.7±4.5 mmHg, p < 0.001) and DAP (109.7±1.9 vs 88.4±2.6 mmHg, p < 0.001) when compared to OWTD, and had lower HR (355.1±8.9 vs 386.8±9.2 bpm, p < 0.05). After spectral analysis of PI and SAP, only LF band of SAP spectrum was higher (7.2±0.8 vs 4.0±0.6 mmHg2) in OMTD under spontaneous condition. Despite bradicardia, EGH promotes spontaneous hypertension in 60 days old offspring, probably due to increased sympathetic activity to vessels, which is suggested by the higher LF of SAP. These findings suggest a critical role of maternal THs in the development of fetal cardiovascular and autonomic nervous system. ; Os hormônios da tireoide (HTs), tiroxina (T4) e triiodotironina (T3), são reconhecidos por influenciar o crescimento e metabolismo celulares em todo o organismo. Os HTs são fundamentais para o bom desenvolvimento embrionário. O hipotireoidismo é uma das doenças endócrinas mais frequentes, acometendo frequentemente mulheres gestantes, sobretudo na forma subclínica (HS). O suprimento de HTs para o feto em praticamente toda a gestação é de origem materna. A deficiência destes hormônios está implicada com desordens no neurodesenvolvimento fetal, assim como no ... |
| نوع الوثيقة: | thesis |
| وصف الملف: | application/pdf |
| اللغة: | Portuguese |
| العلاقة: | https://ri.ufs.br/handle/riufs/3765Test |
| الإتاحة: | https://ri.ufs.br/handle/riufs/3765Test |
| حقوق: | Acesso Aberto |
| رقم الانضمام: | edsbas.C1DBDA82 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |