دورية أكاديمية
Translating Results From the Cardiovascular Outcomes Trials with Glucagon-Like Peptide-1 Receptor Agonists Into Clinical Practice: Recommendations From a Eastern and Southern Europe Diabetes Expert Group
| العنوان: | Translating Results From the Cardiovascular Outcomes Trials with Glucagon-Like Peptide-1 Receptor Agonists Into Clinical Practice: Recommendations From a Eastern and Southern Europe Diabetes Expert Group |
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| المؤلفون: | Janez, A, Muzurovic, E, Stoian, A, Haluzik, M, Guja, C, Czupryniak, L, Duvnjak, L, Lalic, N, Tankova, T, Bogdanski, P, Papanas, N, Silva Nunes, J, Kempler, P, Fras, Z, Rizzo, M |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | Repositório do Centro Hospitalar de Lisboa Central EPE |
| مصطلحات موضوعية: | HCC END, Humans, Cardiovascular Diseases* / drug therapy, Cardiovascular Diseases* / epidemiology, Diabetes Mellitus, Type 2* / diagnosis, Type 2* / drug therapy, Type 2* / epidemiology, Glucagon-Like Peptide 1 / metabolism, Glucagon-Like Peptide-1 Receptor / agonists, Hypoglycemic Agents / pharmacology, Hypoglycemic Agents / therapeutic use, Liraglutide / pharmacology, Liraglutide / therapeutic use |
| الوصف: | Glucagon-like peptide-1 (GLP-1) receptor agonists mimic the action of the endogenous GLP-1 incretin hormone, improving glycaemic control in type 2 diabetes mellitus (T2DM) by increasing insulin secretion and decreasing glucagon secretion in a glucose-dependent manner. However, as cardiovascular (CV) morbidity and mortality is common in patients with T2DM, several trials with the use of GLP-1 receptor agonists (RAs) have been performed focusing on endpoints related to cardiovascular disease rather than metabolic control of T2DM. Following the positive cardiovascular effects of liraglutide, dulaglutide and semaglutide observed in these trials, major changes in T2DM management guidelines have occurred. This document from a Eastern and Southern European Diabetes Expert Group discusses the results of GLP-1 RA CV outcomes trials, their impact on recent clinical guidelines for the management of T2DM, and some selected combination regimens utilising GLP-1 RAs. We also propose an algorithm for guiding GLP-1 RA-based treatment according to patients' characteristics, which can be easily applied in every day clinical practice. ; info:eu-repo/semantics/publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Int J Cardiol . 2022 Oct 15:365:8-18.; http://hdl.handle.net/10400.17/4835Test |
| DOI: | 10.1016/j.ijcard.2022.07.017 |
| الإتاحة: | https://doi.org/10.1016/j.ijcard.2022.07.017Test http://hdl.handle.net/10400.17/4835Test |
| حقوق: | openAccess |
| رقم الانضمام: | edsbas.828B91AA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ijcard.2022.07.017 |
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