التفاصيل البيبلوغرافية
| العنوان: |
The role of irisin on the polarization of monocyte-derived macrophages from pediatric patients with type 2 diabetes mellitus |
| المؤلفون: |
González Gil, Adrián Marcelo |
| المساهمون: |
Elizondo Montemayor, Luz Leticia, School of Medicine and Health Sciences, García Rivas, Gerardo de Jesús, Estrada, Manuel, Genevieve Brunck, Marion Emilie, González Castillo, Elena Cristina, Campus Monterrey, puelquio |
| بيانات النشر: |
Instituto Tecnológico y de Estudios Superiores de Monterrey |
| سنة النشر: |
2022 |
| المجموعة: |
Repositorio del Tecnologico de Monterrey |
| مصطلحات موضوعية: |
MEDICINA Y CIENCIAS DE LA SALUD::CIENCIAS MÉDICAS::MEDICINA INTERNA::ENDOCRINOLOGÍA, Medicine, Irisin, Myokines, Pediatric type 2 diabetes, Monocyte subsets, Monocyte-derived macrophage, Inflammation, Insulin resistance, Pediatric obesity |
| الوصف: |
orcid:0000-0002-2076-1769 ; Irisin is a novel peptide hormone released from skeletal muscle following acute bouts of physical exercise. Besides its originally described role on adipose tissue browning, its direct antiinflammatory properties have been recently described. Specifically, when murine RAW264.7 macrophages were pre-treated with irisin, both gene and protein expression of key proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6, decrease following exposure to lipopolysaccharide (LPS), while levels of the anti-inflammatory cytokine IL-10 increase. These changes have been linked to decreased TLR4 protein expression and activity of NF-ΚB. As well, in murine models, irisin has been described to favor an alternatively activated M2 macrophage phenotype, both from a M0 unstimulated state and a M1 classical proinflammatory state. Recently, the importance of an anti-inflammatory microenvironment to maintain the differentiation and function of brown adipose tissue has been emphasized in preclinical models, which could imply that irisin exerts its global metabolic effects indirectly through its action on adipose tissue macrophages, at least partially. Thus, irisin and its downstream pathways could represent a novel therapeutic target in type 2 diabetes mellitus (T2DM), a disease state characterized by a systemic low-grade proinflammatory state and lower circulating levels of irisin compared with healthy controls. In humans, evidence shows that M1 macrophage infiltrates in adipose tissue originate from circulating monocytes, but no studies have described the role of irisin on any type of human immune cell. ; Using monocyte-derived macrophages (MDMs) obtained from peripheral blood mononuclear cells (PBMCs) from a previously characterized cross-sample of pediatric T2DM patients (n=15) and matched healthy controls (n=8), we sought to determine differences in MDM immunophenotypes between groups, their response to in vitro treatment with recombinant human irisin, and to correlate patients’ basal monocyte subsets ... |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
Texto; application/pdf |
| اللغة: |
English |
| العلاقة: |
versión publicada; Gonzalez-Gil, A. (2021) The role of irisin on the polarization of monocyte-derived macrophages from pediatric patients with type 2 diabetes mellitus. Instituto Tecnologico de y de Estudios Superiores de Monterrey.; https://hdl.handle.net/11285/644257Test; orcid:0000-0002-3379-1916; 1006103; https://www.scopus.com/authid/detail.uri?authorId=57208624497Test |
| الإتاحة: |
https://hdl.handle.net/11285/644257Test
https://www.scopus.com/authid/detail.uri?authorId=57208624497Test |
| حقوق: |
openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0Test |
| رقم الانضمام: |
edsbas.227C0339 |
| قاعدة البيانات: |
BASE |
