دورية أكاديمية
Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults
| العنوان: | Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults |
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| المصدر: | Mediators of Inflammation |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2017 |
| المجموعة: | Repositorio del Tecnologico de Monterrey |
| مصطلحات موضوعية: | 25 hydroxyvitamin D, cytokine, gamma interferon, interleukin 10, interleukin 12p70, interleukin 17, interleukin 1beta, interleukin 23, interleukin 33, interleukin 6, interleukin 8, monocyte chemotactic protein 1, tumor necrosis factor, vitamin D, adult, age, aged, anthropometric parameters, Article, dietary intake, female, human, inflammation, latitude, lifestyle, longitudinal study, major clinical study, male, multivariate analysis, probability |
| الوصف: | Vitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. The same cohort was followed during 12 months. Vitamin D deficiency/insufficiency was found in 91.3% of the subjects despite living in appropriate latitude (25°40′0″N). 25(OH)D levels remained below <30 ng/mL through all seasons. Vitamin D deficiency did not correlate to sun exposure or dietary intake. Gender was the strongest associated factor, explaining a variance of 20%. Waist circumference (WC) greater than 88 cm was a risk factor for vitamin D deficiency. Age (>74 years) combined with WC (>88 cm) and BMI (>32.7) showed a high probability (90%) of vitamin D deficiency. Remarkably, an increase in one centimeter in WC decreased 25(OH)D by 0.176 ng/mL, while an increase in one point BMI decreased 25(OH)D by 0.534 ng/mL. A cutoff point of 74 years of age determined probability of vitamin D hipovitaminosis. Vitamin D deficiency was correlated with TNF-α serum levels, possibly increasing the susceptibility of older adults to a proinflammatory state and its related diseases. © 2017 Leticia Elizondo-Montemayor et al. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030669020&doi=10.1155%2f2017%2f5719461&partnerID=40&md5=2e2efc4bbbee0be261c9f1f4610b4fe2Test; Investigadores; Estudiantes; 9629351; http://hdl.handle.net/11285/630391Test; 2017 |
| DOI: | 10.1155/2017/5719461 |
| الإتاحة: | https://doi.org/10.1155/2017/5719461Test http://hdl.handle.net/11285/630391Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0Test |
| رقم الانضمام: | edsbas.5B2AC870 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2017/5719461 |
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