دورية أكاديمية
Influence of feeding graded levels of canned sardines on the inflammatory markers and tissue fatty acid composition of Wistar rats
| العنوان: | Influence of feeding graded levels of canned sardines on the inflammatory markers and tissue fatty acid composition of Wistar rats |
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| المؤلفون: | Rodrigues, Pedro O, Martins, Susana V, Lopes, Paula A, Ramos, Cristina, Alfaia, Cristina M, Pinto, Rui M A, Rolo, Eva A, Bispo, Paulo F, Batista, Irineu, Bandarra, Narcisa M, Prates, José A M |
| المساهمون: | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Centro de Estudos de Doenças Crónicas (CEDOC) |
| سنة النشر: | 2014 |
| المجموعة: | Repositório da Universidade Nova de Lisboa (UNL) |
| مصطلحات موضوعية: | FISH-OIL, HOMEOSTASIS, SECRETION, CARDIOVASCULAR-DISEASE, LIPID-METABOLISM, DHA, Fatty acid profiles, DOCOSAHEXAENOIC ACID, INSULIN SENSITIVITY, ALPHA-LINOLENIC ACID, Canned sardines, EPA, Cytokines, Wistar rats, PLASMA, N-3 |
| الوصف: | The present study was supported by Fundacao para a Ciencia e a Tecnologia (FCT) through the grant PTDC-SAU/OSM/2006/70560 (principal investigator: P. O. R). S. V. M. is the recipient of a FCT individual fellowship SFRH/BPD/2009/63019 and P. A. L. is a researcher involved in the FCT programme 'Ciencia 2008'. ; Canned sardines are a ready-to-use fish product with excellent nutritional properties owing to its high n-3 long-chain PUFA content, mainly EPA (20 : 5n-3) and DHA (22 : 6n-3). The present study aimed to assess the effect of two dosages of canned sardines, recommended for the primary and secondary prevention of human CVD, on the inflammatory marker concentrations and fatty acid composition of erythrocytes and key metabolic tissues (liver, muscle, adipose tissue and brain) in the rat model. Wistar rats were fed a diet containing 11\% (w/w) of canned sardines (low-sardine (LS) diet) and a diet containing 22\% (w/w) of canned sardines (high-sardine (HS) diet) for 10 weeks. Daily food intake, weight gain, and organ and final body weights were not affected by the dietary treatments. The concentrations of total cholesterol, HDL-cholesterol and LDL-cholesterol decreased in both the LS and HS groups, while those of alanine aminotransferase and adiponectin increased. The concentrations of IL-1 beta increased only with the highest dosage of sardine. The dose-dependent influence of the graded levels of EPA+DHA was tissue specific. Compared with that of other tissues and erythrocytes, the fatty acid composition of the brain was less affected by the canned sardine-supplemented diets. In contrast, the retroperitoneal adipose tissue was highly responsive. The deposition ratios of EPA and DHA indicated that the LS diet was optimal for DHA deposition across the tissues, except in the retroperitoneal adipose tissue. Taken together, our findings indicate that a LS diet positively affects plasma lipid profiles and inflammatory mediators, whereas a HS diet has contradictory effects on IL-1 beta, which, in turn, is not ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0007-1145 |
| العلاقة: | PURE: 390296; PURE UUID: 85f1e00e-da80-4321-946b-f7c72a5d1d84; researchoutputwizard: 45674; PubMed: 24775714; WOS: 000339054100003; Scopus: 84903782997; http://hdl.handle.net/10362/53182Test; https://doi.org/10.1017/S0007114514000853Test |
| DOI: | 10.1017/S0007114514000853 |
| الإتاحة: | https://doi.org/10.1017/S0007114514000853Test http://hdl.handle.net/10362/53182Test |
| حقوق: | openAccess |
| رقم الانضمام: | edsbas.C34FE1DD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00071145 |
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| DOI: | 10.1017/S0007114514000853 |