دورية أكاديمية
Predictors of Cognitive Decline in the Early Stages of Parkinson's Disease: A Brief Cognitive Assessment Longitudinal Study
| العنوان: | Predictors of Cognitive Decline in the Early Stages of Parkinson's Disease: A Brief Cognitive Assessment Longitudinal Study |
|---|---|
| المؤلفون: | Bugalho, Paulo, Baptista, Miguel Viana |
| المساهمون: | Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) |
| سنة النشر: | 2013 |
| المجموعة: | Repositório da Universidade Nova de Lisboa (UNL) |
| مصطلحات موضوعية: | RISK-FACTORS, COHORT, FRONTOTEMPORAL DEMENTIA, IMPAIRMENT, INCIDENT DEMENTIA, NORMATIVE DATA, CLINICAL-TRIAL, FRONTAL ASSESSMENT BATTERY, RATING-SCALE, MINI-MENTAL-STATE |
| الوصف: | Our objectives were to perform a longitudinal assessment of mental status in early stage Parkinson's disease (PD) patients, with brief neuropsychological tests, in order to find predictive factors for cognitive decline. Sixty-one, early stage, and nondemented patients were assessed twice, over a 2-year interval, with a global cognitive test (mini-mental state examination (MMSE)) and a frontal function test (frontal assessment battery (FAB)) and motor function scales. Dementia and hallucinations were diagnosed according to the DSM-IV criteria. Cognitive function scores did not decrease significantly, except for FAB lexical fluency score. Four patients presented with dementia at followup. The MMSE score below cut-off, worse gait dysfunction, the nontremor motor subtype, and hallucinations were significantly related to dementia. Rigidity and speech dysfunction were related to dementia and a decrease in FAB scores. We can conclude that decline in the MMSE and FAB scores is small and heterogeneous in the early stages of PD. Scores below cut-off in the MMSE could be helpful to predict dementia. Nontremor motor deficits could be predictive factors for frontal cognitive decline and dementia. ; publishersversion ; published |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2042-0080 |
| العلاقة: | PURE: 233293; PURE UUID: fb708198-a18b-44f2-9fb5-b7accc18b2c5; researchoutputwizard: 40034; PubMed: 24303226; WOS: 000327145700001; Scopus: 84888871992; ORCID: /0000-0003-2186-9541/work/48136681; http://hdl.handle.net/10362/23560Test; https://doi.org/10.1155/2013/912037Test |
| DOI: | 10.1155/2013/912037 |
| الإتاحة: | https://doi.org/10.1155/2013/912037Test http://hdl.handle.net/10362/23560Test |
| حقوق: | openAccess |
| رقم الانضمام: | edsbas.6EBD9B3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20420080 |
|---|---|
| DOI: | 10.1155/2013/912037 |