دورية أكاديمية
Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis ; A cluster analysis in the worldwide ASAS-PerSpA study
| العنوان: | Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis ; A cluster analysis in the worldwide ASAS-PerSpA study |
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| المؤلفون: | López-Medina, Clementina, Chevret, Sylvie, Molto, Anna, Sieper, Joachim, Duruöz, Tuncay, Kiltz, Uta, Elzorkany, Bassel, Hajjaj-Hassouni, Najia, Burgos-Vargas, Ruben, Maldonado-Cocco, José, Ziade, Nelly, Gavali, Meghna, Navarro-Compan, Victoria, Luo, Shue Fen, Biglia, Alessandro, Tae-Jong, Kim, Kishimoto, Mitsumasa, Pimentel-Santos, Fernando M., Gu, Jieruo, Muntean, Laura, Van Gaalen, Floris A., Geher, Pál, Magrey, Marina, Ibáñez-Vodnizza, Sebastián E., Bautista-Molano, Wilson, Maksymowych, Walter, MacHado, Pedro M., Landewé, Robert, Van Der Heijde, Desirée, Dougados, Maxime |
| المساهمون: | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) |
| سنة النشر: | 2021 |
| المجموعة: | Repositório da Universidade Nova de Lisboa (UNL) |
| مصطلحات موضوعية: | ankylosing, arthritis, psoriatic, spondylitis, Immunology and Allergy, Rheumatology, Immunology |
| الوصف: | Objective To identify clusters of peripheral involvement according to the specific location of peripheral manifestations (ie, arthritis, enthesitis and dactylitis) in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), and to evaluate whether these clusters correspond with the clinical diagnosis of a rheumatologist. Methods Cross-sectional study with 24 participating countries. Consecutive patients diagnosed by their rheumatologist as PsA, axial SpA or peripheral SpA were enrolled. Four different cluster analyses were conducted: one using information on the specific location from all the peripheral manifestations, and a cluster analysis for each peripheral manifestation, separately. Multiple correspondence analyses and k-means clustering methods were used. Distribution of peripheral manifestations and clinical characteristics were compared across the different clusters. Results The different cluster analyses performed in the 4465 patients clearly distinguished a predominantly axial phenotype (cluster 1) and a predominantly peripheral phenotype (cluster 2). In the predominantly axial phenotype, hip involvement and lower limb large joint arthritis, heel enthesitis and lack of dactylitis were more prevalent. In the predominantly peripheral phenotype, different subgroups were distinguished based on the type and location of peripheral involvement: a predominantly involvement of upper versus lower limbs joints, a predominantly axial enthesitis versus peripheral enthesitis, and predominantly finger versus toe involvement in dactylitis. A poor agreement between the clusters and the rheumatologist € s diagnosis as well as with the classification criteria was found. Conclusion These results suggest the presence of two main phenotypes (predominantly axial and predominantly peripheral) based on the presence and location of the peripheral manifestations. ; publishersversion ; published |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2044-6055 |
| العلاقة: | PURE: 35022362; PURE UUID: 9202da7b-2296-40c3-8c72-f0009e8032fe; Scopus: 85119191865; http://hdl.handle.net/10362/129001Test; https://doi.org/10.1136/rmdopen-2021-001728Test |
| DOI: | 10.1136/rmdopen-2021-001728 |
| الإتاحة: | https://doi.org/10.1136/rmdopen-2021-001728Test http://hdl.handle.net/10362/129001Test |
| حقوق: | openAccess |
| رقم الانضمام: | edsbas.241D7E4C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20446055 |
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| DOI: | 10.1136/rmdopen-2021-001728 |