التفاصيل البيبلوغرافية
| العنوان: |
The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease |
| المؤلفون: |
de Oliveira, R.M., Vicente Miranda, H., Francelle, L., Pinho, R., Szegö, É.M., Martinho, R., Munari, F., Lázaro, D.F., Moniot, S., Guerreiro, P., Fonseca, L., Marijanovic, Z., Antas, P., Gerhardt, E., Enguita, F.J., Fauvet, B., Penque, D., Pais, T.F., Tong, Q., Becker, S., Kügler, S., Lashuel, H.A., Steegborn, C., Zweckstetter, M., Outeiro, T.F. |
| المساهمون: |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Centro de Estudos de Doenças Crónicas (CEDOC) |
| سنة النشر: |
2017 |
| المجموعة: |
Repositório da Universidade Nova de Lisboa (UNL) |
| مصطلحات موضوعية: |
1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine, alpha synuclein, lysine, protein aggregate, protein binding, sirtuin 2, acetylation, animal, autophagy, brain cortex, C57BL mouse, cell culture, cell membrane, disease model, dopaminergic nerve cell, drug effects, gene deletion, gene silencing, genetics, HEK293 cell line, human, knockout mouse, metabolism, mutation, neuroprotection, Parkinson disease, pathology, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, alpha-Synuclein, Animals |
| الوصف: |
14834). Received by CS. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Fundacao para a Ciencia e Tecnologia https://www.fct.pt/index.phtml.enTest (grant number SFRH/BPD/41416/2007; SFRH/BPD/64702/2009; SFRH/BPD/109347/2015; SFRH/BD/61495/2009; Ciencia, 2007; SAU-NEU/105215/2008;). Received by RMO, HVM, PG, TFP, TFO. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Dorothea Schlozer Program (University of Gottingen). Received by EMS. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. JPND: Denmark, Innofond; Germany, BMBF; Sweden, SRC; Switzerland, SNSF; United Kingdom, Medical Research Council www.jpnd.eu. Received by TFO. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Alexander-von-Humboldt Research Fellowship for Postdoctoral Researchers https.//www.humboldt-foundation.de/web/humboldt-fellowship-postdoc.html. Received by LF. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain http://www.cnmpb.de/index.php?lang=en_ENTest. Received by TFO and MZ. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. EU Joint Programme - Neurodegenerative Disease Research (JPND) project http://www.neurodegenerationresearch.euTest (aSynProtec). Received by TFO. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ; Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
1544-9173 |
| العلاقة: |
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F41416%2F2007/PT; info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F61495%2F2009/PT; info:eu-repo/grantAgreement/FCT/3599-PPCDT/105215/PT; FP7 http://www.mefopa.euTest (MEFOPA). Received by TFO. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. EMBO http://www.embo.orgTest (Installation Grant). Received by TFO. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. US Department of Agriculture grant https.//www.usda.gov/wps/portal/usda/usdahorne (grant number 3092-5-001-059). Received by QT. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. American Heart Associate http://www.heart.org/NEARTORGTest/ (grant number AHA-TX 17220055). Received by QT. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Alzheimer Forschung Initiative e.V. https://www.alzheimer-forschung.deTest (grant number AFI; PURE: 3226750; PURE UUID: d9718d3c-b239-47e9-bf8e-5ae461e82048; RIS: urn:8DEF82E075436DD79B4BF80557C66945; Scopus: 85016962065; PubMed: 28257421; PubMedCentral: PMC5336201; WOS: 000397909600002; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016962065&doi=10.1371%2fjournal.pbio.2000374&partnerID=40&md5=dad5e901b648ba86ff17835f4f29726dTest; https://doi.org/10.1371/journal.pbio.2000374Test |
| DOI: |
10.1371/journal.pbio.2000374 |
| الإتاحة: |
https://doi.org/10.1371/journal.pbio.2000374Test |
| حقوق: |
openAccess |
| رقم الانضمام: |
edsbas.A597B5E3 |
| قاعدة البيانات: |
BASE |
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