دورية أكاديمية
High Serum Cyclophilin C levels as a risk factor marker for Coronary Artery Disease
| العنوان: | High Serum Cyclophilin C levels as a risk factor marker for Coronary Artery Disease |
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| المؤلفون: | Alfonso, A, Bayón, J, Gegunde, S, Alonso, E, Alvariño, R, Santás-Álvarez, M, Testa-Fernández, A, Rios-Vázquez, R, González-Juanatey, C, Botana, L |
| المساهمون: | Centro Interdisciplinar de Investigação Marinha e Ambiental |
| بيانات النشر: | Nature |
| سنة النشر: | 2019 |
| المجموعة: | Repositório Aberto da Universidade do Porto |
| مصطلحات موضوعية: | Cardiovascular biology, Diagnostic markers |
| الوصف: | Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistently associated with inflammatory and cardiovascular diseases. While levels of CypA have been extensively studied, less data are available for other Cyps. The purpose of this case-control study was to determine the relationship of Cyps (A, B, C and D) with coronary artery disease (CAD) and eight inflammation markers. Serum levels of Cyps, interleukins and metalloproteinases were measured in serum collected from 84 subjects. Participants were divided into two sub-groups based on CAD diagnosis: 40 CAD patients and 44 control volunteers. Serum levels of CypA, CypB and CypC, IL-1β and IL-6 were significantly higher in CAD patients. Bivariate correlation analysis revealed a significant positive correlation between Cyps and several blood and biochemical parameters. When the ability of Cyps levels for CAD diagnosis was evaluated, higher sensitivity and selectivity values were obtained with CypC (c-statistic 0.891, p < 0.001) indicating that it is a good marker of CAD disease, while less conclusive results were obtained with CypA (c-statistic 0.748, p < 0.001) and CypB (c-statistic 0.655, p < 0.014). In addition, significant correlations of traditional CAD risk factors and CypC were observed. In summary, high levels of CypC are a risk factor for CAD and therefore it can be proposed as a new biomarker for this disease. ; This work could not have been done without the invaluable collaboration of the staff at the Servicio Vixilancia da Saude from Universidad de Santiago de Compostela (Andrea Vidal Dopazo) and at the Cardiology Department, Hospital Universitario Lucus Augusti (Maria Jesús Basanta-Castro, Maria del Carmen Cabarcos Leal, Clara Jimenez-Serrano, Leonor Ortega- Fernández, Maria Jesus Palacios Pool, Sofía Seco-Aldegunde). The research leading to these results has received funding from the following FEDER cofunded-grants. From Conselleria de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, 2017 GRC ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Scientific Reports (2019) 9:10576; https://hdl.handle.net/10216/129835Test; https://doi.org/10.1038/s41598-019-46988-xTest |
| DOI: | 10.1038/s41598-019-46988-x |
| الإتاحة: | https://doi.org/10.1038/s41598-019-46988-xTest https://hdl.handle.net/10216/129835Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B541BA91 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-019-46988-x |
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