دورية أكاديمية
Association between serum Vitamin D and diabetic retinopathy in Portuguese patients with type 1 diabetes
| العنوان: | Association between serum Vitamin D and diabetic retinopathy in Portuguese patients with type 1 diabetes |
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| المؤلفون: | Lopes, M, Laiginhas, R, Madeira, C, Neves, JS, Barbosa, M, Rosas, V, Carvalho, D, Falcão-Reis, F, Falcão, M |
| المساهمون: | Instituto de Investigação e Inovação em Saúde |
| بيانات النشر: | Ordem dos Médicos |
| سنة النشر: | 2020 |
| المجموعة: | Repositório Aberto da Universidade do Porto |
| مصطلحات موضوعية: | Diabetes Mellitus, Diabetic Retinopathy, Portugal, Type 1, Vitamin D, Vitamin D Deficiency, Adult, Type 1 / blood, Type 1 / complications, Type 1 / epidemiology, Diabetic Retinopathy / blood, Diabetic Retinopathy / complications, Diabetic Retinopathy / epidemiology, Female, Humans, Male, Middle Aged, Portugal / epidemiology, Retrospective Studies, Risk Factors, Vitamin D / analogs & derivatives, Vitamin D / blood, Vitamin D Deficiency / blood, Vitamin D Deficiency / epidemiology |
| الوصف: | Introduction: Recently, vitamin D has gained importance as a diabetes risk modifier. Our aim was to assess the association between serum vitamin D levels and the prevalence of diabetic retinopathy in patients with type 1 diabetes. Material and Methods: Retrospective review of a population of patients with type 1 diabetes followed in a Portuguese tertiary center. Patients were included if they had an ophthalmological evaluation and a serum 25-hydroxyvitamin D level determination within the same year. Logistic regression analysis was used to adjust for possible confounders. Results: We included 182 patients (47% male), and 57% (n = 103) had signs of diabetic retinopathy. We found a significant association between lower circulating levels of 25-hydroxyvitamin D levels and a greater prevalence of diabetic retinopathy after adjusting for confounders (duration of diabetes, estimated glomerular filtration rate, age, sex, metabolic control, season, dyslipidemia and hypertension) (OR = 0.94; 95% CI 0.90 - 0.99, p = 0.023). Longer duration of diabetes and worse metabolic control also remained associated with diabetic retinopathy in the multivariate analysis (OR = 1.20; 95% CI 1.13 - 1.27, p < 0.001 and OR = 4.13; 95% CI 1.34 - 12.7, p = 0.013, respectively). Conclusion: Lower levels of vitamin D were associated with an increased prevalence of diabetic retinopathy in patients with type 1 diabetes, after adjusting for possible confounders. Future controlled studies may elucidate the molecular routes for this association as well as the role of supplementation in the prevention of diabetes microvascular complications. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0870-399X |
| العلاقة: | Acta Medica Portuguesa, vol.33(7), p. 459-465; https://actamedicaportuguesa.com/revista/index.php/amp/article/view/12890Test; https://hdl.handle.net/10216/143523Test |
| DOI: | 10.20344/amp.12890 |
| الإتاحة: | https://doi.org/10.20344/amp.12890Test https://hdl.handle.net/10216/143523Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AD1CA872 |
| قاعدة البيانات: | BASE |
| تدمد: | 0870399X |
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| DOI: | 10.20344/amp.12890 |