دورية أكاديمية
Induced Sputum MMP-1, -3 & -8 Concentrations during Treatment of Tuberculosis
| العنوان: | Induced Sputum MMP-1, -3 & -8 Concentrations during Treatment of Tuberculosis |
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| المؤلفون: | Ugarte-Gil, Cesar A., Elkington, Paul, Gilman, Robert H., Coronel, Jorge, Tezera, Liku B., Bernabe-Ortiz, Antonio, Gotuzzo, Eduardo, Friedland, Jon S., Moore, David A. J. |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2013 |
| المجموعة: | Repositorio - UPCH (Universidad Peruana Cayetano Heredia) |
| مصطلحات موضوعية: | Cross-Sectional Studies, Humans, Case-Control Studies, Longitudinal Studies, Culture Techniques, Antitubercular Agents, Matrix Metalloproteinase 1, Matrix Metalloproteinase 3, Matrix Metalloproteinase 8, Matrix Metalloproteinases, Secreted, Sputum, Tissue Inhibitor of Metalloproteinases, Tuberculosis, https://purl.org/pe-repo/ocde/ford#3.03.08Test |
| الوصف: | Introduction: Tuberculosis (TB) destroys lung tissues and this immunopathology is mediated in part by Matrix Metalloproteinases (MMPs). There are no data on the relationship between local tissue MMPs concentrations, anti-tuberculosis therapy and sputum conversion. Materials and Methods: Induced sputum was collected from 68 TB patients and 69 controls in a cross-sectional study. MMPs concentrations were measured by Luminex array, TIMP concentrations by ELISA and were correlated with a disease severity score (TBscore). 46 TB patients were then studied longitudinally at the 2nd, 8th week and end of treatment. Results: Sputum MMP-1,-2,-3,-8,-9 and TIMP-1 and -2 concentrations are increased in TB. Elevated MMP-1 and -3 concentrations are independently associated with higher TB severity scores (p<0.05). MMP-1, -3 and -8 concentrations decreased rapidly during treatment (p<0.05) whilst there was a transient increase in TIMP-1/2 concentrations at week 2. MMP-2, -8 and -9 and TIMP-2 concentrations were higher at TB diagnosis in patients who remain sputum culture positive at 2 weeks and MMP-3, -8 and TIMP-1 concentrations were higher in these patients at 2nd week of TB treatment. Conclusions: MMPs are elevated in TB patients and associate with disease severity. This matrix-degrading phenotype resolves rapidly with treatment. The MMP profile at presentation correlates with a delayed treatment response. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | urn:issn:1932-6203; https://hdl.handle.net/20.500.12866/10689Test; PLoS ONE; https://doi.org/10.1371/journal.pone.0061333Test |
| DOI: | 10.1371/journal.pone.0061333 |
| الإتاحة: | https://doi.org/20.500.12866/10689Test https://doi.org/10.1371/journal.pone.0061333Test https://hdl.handle.net/20.500.12866/10689Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess ; https://creativecommons.org/licenses/by-nc-nd/4.0/deed.esTest |
| رقم الانضمام: | edsbas.7C7A21E2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0061333 |