دورية أكاديمية
Selection of sucrose concentration depends on the effort required to obtain it: studies using tetrabenazine, D1, D2, and D3 receptor antagonists
| العنوان: | Selection of sucrose concentration depends on the effort required to obtain it: studies using tetrabenazine, D1, D2, and D3 receptor antagonists |
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| المؤلفون: | Pardo Andrés, Marta, López Cruz, Laura, San Miguel Segura, Noemí, Salamone, John, Correa, Merce |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 2016 |
| المجموعة: | Repositori Universitat Jaume I (Repositorio UJI) |
| مصطلحات موضوعية: | Motivation, Anergia, Anhedonia, Dopamine, Decision making, Depression |
| الوصف: | Rationale Low doses of dopamine (DA) antagonists and accumbens DA depletions reduce food-reinforced instrumental behavior but do not impair primary food motivation, causing animals to reallocate behavior away from food-reinforced tasks with high response requirements and select less effortful alternatives. However, it is uncertain if this same pattern of effects would occur if sucrose was used as the reinforcer. Objectives These experiments studied the impact of DA depletion and antagonism on performance of an effort-related choice task using sucrose as the reinforcer, as well as sucrose consumption, preference, and taste reactivity tests. Methods The effects of DA manipulations were assessed using a task in which rats chose between lever pressing on a fixed ratio 7 schedule for 5.0 % sucrose versus freely consuming a less concentrated solution (0.3 %). Results The DA depleting agent tetrabenazine shifted effortrelated choice, decreasing lever pressing for 5.0 % sucrose but increasing intake of the concurrently available 0.3 % sucrose. Tetrabenazine did not affect sucrose appetitive taste reactivity, or sucrose consumption or preference, in free consumption tests. The D1 antagonist ecopipam and the D2 antagonist haloperidol also shifted choice behavior at doses that did not alter sucrose consumption or preference. In contrast, sucrose preexposure reduced consumption across all conditions. D3 antagonism had no effects. Conclusions D1 and D2 receptor blockade and DA depletion reduce the tendency to work for sucrose under conditions that leave fundamental aspects of sucrose motivation (intake, preference, hedonic reactivity) intact. These findings have implications for studies employing sucrose intake or preference in animal models of depression. ; This work was supported by a grant to Mercè Correa from Pla Promoció Investigació UJI (P1.1 A 2013-01) and to John D. Salamone from the National Institute of Mental Health (MH078023). Personal grants were awarded to Marta Pardo (Predoc-UJI/ 2007/43), Noemí San Miguel ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1432-2072 0033-3158 |
| العلاقة: | Psychopharmacology (2015) 232:2377–2391; http://link.springer.com/article/10.1007/s00213-015-3872-7Test; http://hdl.handle.net/10234/160655Test; http://dx.doi.org/10.1007/s00213-015-3872-7Test |
| DOI: | 10.1007/s00213-015-3872-7 |
| الإتاحة: | https://doi.org/10.1007/s00213-015-3872-7Test http://hdl.handle.net/10234/160655Test |
| حقوق: | © Springer-Verlag Berlin Heidelberg 2015 ; http://rightsstatements.org/vocab/InC/1.0Test/ ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.8E239B77 |
| قاعدة البيانات: | BASE |
| تدمد: | 14322072 00333158 |
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| DOI: | 10.1007/s00213-015-3872-7 |