دورية أكاديمية
QRS duration reflects underlying changes in conduction velocity during increased intraventricular pressure and heart failure
| العنوان: | QRS duration reflects underlying changes in conduction velocity during increased intraventricular pressure and heart failure |
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| المؤلفون: | Quintanilla, Jorge G., Moreno, Javier, Archondo, Tamara, Alfonso-Almazan, Jose M., Lillo-Castellano, Jose Maria, Usandizaga, Elena, García-Torrent, María Jesús, Rodríguez-Bobada, Cruz, González, Pablo, Borrego, Luis, Cañadas-Godoy, Victoria, González-Ferrer, Juan J, Pérez-Castellano, Nicasio, Pérez-Villacastín, Julián, Filgueiras-Rama, David |
| المساهمون: | Ministerio de Economía, Industria y Competitividad (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Instituto de Salud Carlos III, Fundación ProCNIC |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | Afterload, Heart failure, Intraventricular pressure, Optical mapping, Remodeling, Animals, Heart Conduction System, Swine, Electrocardiography, Ventricular Pressure |
| الوصف: | Pressure overload and heart failure electrophysiological remodeling (HF-ER) in pigs are associated with decreased conduction velocity (CV) and dispersion of repolarization, which lead to higher risk of ventricular arrhythmia. This work aimed to establish the correlation between QRS complex duration and underlying changes in CV during increased intraventricular pressure (IVP) and/or HF-ER ex-vivo, and to determine whether QRS duration could be sensitive to an acute increase in left ventricular (LV) afterload in-vivo. HF-ER was induced in 7 pigs by high-rate ventricular pacing. Seven weight-matched animals were used as controls. Isolated Langendorff-perfused hearts underwent programmed ventricular stimulation to study QRS complex duration and CV under low/high IVP, using volume-conducted ECG and epicardial optical mapping, respectively. Four additional pigs underwent open-chest surgery to increase LV afterload by partially clamping the ascending aorta, while measuring QRS complex duration during sinus rhythm (SR). In 13 hearts included for analysis, both HF-ER and increased IVP showed significantly slower epicardial CV (-40% and -15%, p < 0.001 and p = 0.004, respectively), which correlated with similar widening of the QRS complex (+41% and +17%, p = 0.005 and p < 0.001, respectively). HF-ER hearts shower larger prolongation of the QRS complex than controls upon increasing the IVP (+21% vs. +12%, respectively. HF-ER*IVP interaction: p = 0.004). QRS complex widened after increasing LV afterload in-vivo (n=3), with correlation between QRS duration and aortic diastolic pressures (R = 0.58, p < 0.001). In conclusion, high IVP and/or HF-ER significantly decrease CV, which correlates with QRS widening on the ECG during ventricular pacing. Increased myocardial wall stress also widens the QRS complex during SR in-vivo. ; The CNIC is supported by the Ministry of Economy, Industry and Competitiveness and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). This study was supported by ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0079-6107 1873-1732 |
| العلاقة: | Postprint; https://doi.org/10.1016/j.pbiomolbio.2017.08.003Test; info:eu-repo/grantAgreement/ES/SEV-2015-0505; info:eu-repo/grantAgreement/ES/CB16/11/00458; info:eu-repo/grantAgreement/ES/RD06/0003/0009; info:eu-repo/grantAgreement/ES/RD12/0042/0036; info:eu-repo/grantAgreement/ES/SAF2016-80324-R; Prog Biophys Mol Biol. 2017; 130(Pt B):394-403; http://hdl.handle.net/20.500.12105/9908Test; Progress in biophysics and molecular biology |
| DOI: | 10.1016/j.pbiomolbio.2017.08.003 |
| الإتاحة: | https://doi.org/20.500.12105/9908Test https://doi.org/10.1016/j.pbiomolbio.2017.08.003Test https://hdl.handle.net/20.500.12105/9908Test |
| حقوق: | http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EC4C1183 |
| قاعدة البيانات: | BASE |
| تدمد: | 00796107 18731732 |
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| DOI: | 10.1016/j.pbiomolbio.2017.08.003 |