دورية أكاديمية
Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study
| العنوان: | Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study |
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| المؤلفون: | Jimenez-Sousa, Maria Angeles, López, Elisabeth, Fernandez-Rodriguez, Amanda, Tamayo, Eduardo, Fernandez-Navarro, Pablo L, Segura-Roda, Laura, Heredia, María, Gómez-Herreras, José I, Bustamante, Jesús, García-Gómez, Juan Miguel, Bermejo-Martin, Jesús F, Resino, Salvador |
| المساهمون: | Instituto de Salud Carlos III, Junta de Castilla y León (España) |
| بيانات النشر: | BioMed Central (BMC) |
| سنة النشر: | 2012 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | Aged, Case-Control Studies, Chemokine CCL2, Female, Genetic Predisposition to Disease, Genotype, Humans, Immune System, Inflammation, Kidney Failure, Chronic, Male, Middle Aged, Models, Genetic, Nitric Oxide Synthase Type III, Receptors, Interleukin-4, Regression Analysis, Retrospective Studies, STAT4 Transcription Factor, Polymorphism |
| الوصف: | BACKGROUND: Chronic kidney disease progression has been linked to pro-inflammatory cytokines and markers of inflammation. These markers are also elevated in end-stage renal disease (ESRD), which constitutes a serious public health problem. OBJECTIVE: To investigate whether single nucleotide polymorphisms (SNPs) located in genes related to immune and inflammatory processes, could be associated with ESRD development. DESIGN AND METHODS: A retrospective case-control study was carried out on 276 patients with ESRD and 288 control subjects. Forty-eight SNPs were genotyped via SNPlex platform. Logistic regression was used to assess the relationship between each sigle polymorphism and the development of ESRD. RESULTS: Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model). After adjusting for multiple testing, results lost significance. CONCLUSION: Our preliminary data suggest that four genetic polymorphisms located in genes related to inflammation and immune processes could help to predict the risk of developing ESRD. ; This work was supported by grants from Instituto de Salud Carlos III (Ref: PI08/0738 and PI11/00245) to SR and Junta de Castilla y León (Ref: GRS 234/A/08) to ET. MAJS is supported by a grant from Instituto de Salud Carlos III (CM10/00105). ; Sí |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2350 22817530 |
| العلاقة: | https://doi.org/10.1186/1471-2350-13-58Test; info:eu-repo/grantAgreement/ES/PI08/0738; info:eu-repo/grantAgreement/ES/PI11/00245; BMC Med Genet. 2012 Jul 20;13:58.; http://hdl.handle.net/20.500.12105/7065Test; BMC medical genetics |
| DOI: | 10.1186/1471-2350-13-58 |
| الإتاحة: | https://doi.org/20.500.12105/7065Test https://doi.org/10.1186/1471-2350-13-58Test https://hdl.handle.net/20.500.12105/7065Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; Atribución 4.0 Internacional ; open access |
| رقم الانضمام: | edsbas.2BA98604 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712350 22817530 |
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| DOI: | 10.1186/1471-2350-13-58 |