دورية أكاديمية
Estimating seroprevalence of vaccine-preventable infections: is it worth standardizing the serological outcomes to adjust for different assays and laboratories?
| العنوان: | Estimating seroprevalence of vaccine-preventable infections: is it worth standardizing the serological outcomes to adjust for different assays and laboratories? |
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| المؤلفون: | Kafatos, G, Andrews, N, McConway, K J, Anastassopoulou, C, Barbara, C, De Ory, Fernando, Johansen, K, Mossong, J, Prosenc, K, Vranckx, R, Nardone, A, Pebody, R, Farrington, P |
| المساهمون: | European Commission |
| بيانات النشر: | Cambridge University Press |
| سنة النشر: | 2015 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | ESEN2, Seroprevalence, Serosurvey, Standardization, Vaccination, Adolescent, Adult, Chickenpox, Child, Preschool, Diphtheria, Diphtheria Toxoid, Europe, Hepatitis A, Humans, Infant, Measles, Mumps, Reference Standards, Rubella, Seroepidemiologic Studies, Viral Vaccines, Young Adult |
| الوصف: | The aim of the European Sero-Epidemiology Network 2 (ESEN2) project was to estimate age-specific seroprevalence for a number of vaccine-preventable diseases in Europe. To achieve this serosurveys were collected by 22 national laboratories. To adjust for a variety of laboratory methods and assays, all quantitative results were transformed to a reference laboratory's units and were then classified as positive or negative to obtain age-specific seroprevalence. The aim of this study was to assess the value of standardization by comparing the crude and standardized seroprevalence estimates. Seroprevalence was estimated for measles, mumps, rubella, diphtheria, varicella zoster and hepatitis A virus (HAV) and compared before and after serological results had been standardized. The results showed that if no such adjustment had taken place, seroprevalence would have differed by an average of 3·2% (95% bootstrap interval 2·9-3·6) although this percentage varied substantially by antigen. These differences were as high as 16% for some serosurveys (HAV) which means that standardization could have a considerable impact on seroprevalence estimates and should be considered when comparing serosurveys performed in different laboratories using different assay methods. ; We thank all the ESEN2 members who contributed to the collection and testing of the serological samples included in this paper. The ESEN2 project was funded by the European Commission (contract number QLK2-CT-2000–00542), national governments and other national funding sources. ; Sí |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1469-4409 |
| العلاقة: | Publisher's version; https://doi.org/10.1017/S095026881400301XTest; info:eu-repo/grantAgreement/EU/QLK2-CT-2000–00542; Epidemiol Infect. 2015 Aug;143(11):2269-78.; http://hdl.handle.net/20.500.12105/11473Test; Epidemiology and infection |
| DOI: | 10.1017/S095026881400301X |
| الإتاحة: | https://doi.org/20.500.12105/11473Test https://doi.org/10.1017/S095026881400301XTest https://hdl.handle.net/20.500.12105/11473Test |
| حقوق: | http://creativecommons.org/licenses/by-nc-sa/4.0Test/ ; Atribución-NoComercial-CompartirIgual 4.0 Internacional ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6CDAC72D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14694409 |
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| DOI: | 10.1017/S095026881400301X |