دورية أكاديمية
Mortality, Causes of Death and Associated Factors Relate to a Large HIV Population-Based Cohort
| العنوان: | Mortality, Causes of Death and Associated Factors Relate to a Large HIV Population-Based Cohort |
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| المؤلفون: | Garriga, Cesar, García de Olalla, Patricia, Miró, Josep M, Ocaña, Inma, Knobel, Hernando, Barbera, Maria Jesus, Humet, Victoria, Domingo, Pere, Gatell, Josep M, Ribera, Esteve, Gurguí, Mercè, Marco, Andrés, Caylà, Joan A |
| المساهمون: | Instituto de Salud Carlos III |
| بيانات النشر: | Public Library of Science (PLOS) |
| سنة النشر: | 2015 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | Acquired Immunodeficiency Syndrome, Adult, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Cause of Death, Cohort Studies, Drug Users, Female, HIV Infections, Heterosexuality, Homosexuality, Male, Humans, Kaplan-Meier Estimate, Risk Factors, Substance Abuse, Intravenous |
| الوصف: | INTRODUCTION: Antiretroviral therapy has led to a decrease in HIV-related mortality and to the emergence of non-AIDS defining diseases as competing causes of death. This study estimates the HIV mortality rate and their risk factors with regard to different causes in a large city from January 2001 to June 2013. MATERIALS AND METHODS: We followed-up 3137 newly diagnosed HIV non-AIDS cases. Causes of death were classified as HIV-related, non-HIV-related and external. We examined the effect of risk factors on survival using mortality rates, Kaplan-Meier plots and Cox models. Finally, we estimated survival for each main cause of death groups through Fine and Gray models. MORTALITY RESULTS: 182 deaths were found [14.0/1000 person-years of follow-up (py); 95% confidence interval (CI):12.0-16.1/1000 py], 81.3% of them had a known cause of death. Mortality rate by HIV-related causes and non-HIV-related causes was the same (4.9/1000 py; CI:3.7-6.1/1000 py), external was lower [1.7/1000 py; (1.0-2.4/1000 py)]. SURVIVAL RESULTS: Kaplan-Meier estimate showed worse survival in intravenous drug user (IDU) and heterosexuals than in men having sex with men (MSM). Factors associated with HIV-related causes of death include: IDU male (subHazard Ratio (sHR):3.2; CI:1.5-7.0) and <200 CD4 at diagnosis (sHR:2.7; CI:1.3-5.7) versus ≥500 CD4. Factors associated with non-HIV-related causes of death include: ageing (sHR:1.5; CI:1.4-1.7) and heterosexual female (sHR:2.8; CI:1.1-7.3) versus MSM. Factors associated with external causes of death were IDU male (sHR:28.7; CI:6.7-123.2) and heterosexual male (sHR:11.8; CI:2.5-56.4) versus MSM. CONCLUSION AND RECOMMENDATION: There are important differences in survival among transmission groups. Improved treatment is especially necessary in IDUs and heterosexual males. ; The work was supported by 12/PEAC-06, Programa de Epidemiología Aplicada de Campo (Field Epidemiology Training Programme), Instituto de Salud Carlos III (Carlos III Public Health Institute). The funders had no role in study ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | https://doi.org/10.1371/journal.pone.0145701Test; PLoS One. 2015 Dec 30;10(12):e0145701.; http://hdl.handle.net/20.500.12105/6834Test; PloS one |
| DOI: | 10.1371/journal.pone.0145701 |
| الإتاحة: | https://doi.org/20.500.12105/6834Test https://doi.org/10.1371/journal.pone.0145701Test https://hdl.handle.net/20.500.12105/6834Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; Atribución-4.0 Internacional ; open access |
| رقم الانضمام: | edsbas.9776740A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0145701 |