دورية أكاديمية
Analysis of vulnerability to reentry in acute myocardial ischemia using a realistic human heart model
| العنوان: | Analysis of vulnerability to reentry in acute myocardial ischemia using a realistic human heart model |
|---|---|
| المؤلفون: | Carpio E. F., Gomez J. F., Rodriguez-Matas J. F., Trenor B., Ferrero J. M. |
| المساهمون: | Carpio, E. F., Gomez, J. F., Rodriguez-Matas, J. F., Trenor, B., Ferrero, J. M. |
| سنة النشر: | 2022 |
| المجموعة: | RE.PUBLIC@POLIMI - Research Publications at Politecnico di Milano |
| مصطلحات موضوعية: | Acute myocardial ischemia, Computational modeling, His-purkinje system, Ventricular arrhythmias, Vulnerability to reentry |
| الوصف: | Electrophysiological alterations of the myocardium caused by acute ischemia constitute a pro-arrhythmic substrate for the generation of potentially lethal arrhythmias. Experimental evidence has shown that the main components of acute ischemia that induce these electrophysiological alterations are hyperkalemia, hypoxia (or anoxia in complete artery occlusion), and acidosis. However, the influence of each ischemic component on the likelihood of reentry is not completely established. Moreover, the role of the His-Purkinje system (HPS) in the initiation and maintenance of arrhythmias is not completely understood. In the present work, we investigate how the three components of ischemia affect the vulnerable window (VW) for reentry using computational simulations. In addition, we analyze the role of the HPS on arrhythmogenesis. A 3D biventricular/torso human model that includes a realistic geometry of the central and border ischemic zones with one of the most electrophysiologically detailed model of ischemia to date, as well as a realistic cardiac conduction system, were used to assess the VW for reentry. Four scenarios of ischemic severity corresponding to different minutes after coronary artery occlusion were simulated. Our results suggest that ischemic severity plays an important role in the generation of reentries. Indeed, this is the first 3D simulation study to show that ventricular arrhythmias could be generated under moderate ischemic conditions, but not in mild and severe ischemia. Moreover, our results show that anoxia is the ischemic component with the most significant effect on the width of the VW. Thus, a change in the level of anoxia from moderate to severe leads to a greater increment in the VW (40 ms), in comparison with the increment of 20 ms and 35 ms produced by the individual change in the level of hyperkalemia and acidosis, respectively. Finally, the HPS was a necessary element for the generation of approximately 17% of reentries obtained. The retrograde conduction from the myocardium to HPS in ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34836624; info:eu-repo/semantics/altIdentifier/wos/WOS:000788084400003; volume:141; firstpage:1; lastpage:15; numberofpages:15; journal:COMPUTERS IN BIOLOGY AND MEDICINE; http://hdl.handle.net/11311/1204333Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85119920284 |
| DOI: | 10.1016/j.compbiomed.2021.105038 |
| الإتاحة: | https://doi.org/10.1016/j.compbiomed.2021.105038Test http://hdl.handle.net/11311/1204333Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EF02C46D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.compbiomed.2021.105038 |
|---|