دورية أكاديمية
Genetic Variation at 16q24.2 is associated with small vessel stroke.
| العنوان: | Genetic Variation at 16q24.2 is associated with small vessel stroke. |
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| المؤلفون: | Traylor, M., Malik, R., Nalls, M. A., Cotlarciuc, I., Radmanesh, F., Thorleifsson, G., Hanscombe, K. B., Langefeld, C., Saleheen, D., Rost, N. S., Yet, I., Spector, T. D., Bell, J. T., Hannon, E., Mill, Jonathan, Chauhan, G., Debette, S., Bis, J.C., Longstreth, W. T., Ikram, M. A., Launer, L. J., Seshadri, S., Jimenez-Conde, J., Cole, J. W., Schmidt, R., Słowik, A., Lemmens, R., Lindgren, A., Melander, O., Grewal, R. P., Sacco, R. L., Rundek, T., Rexrode, K., Arnett, D. K., Johnson, J. A., Benavente, O. R., Wasssertheil-Smoller, S., Lee, J-M, Pulit, S. L., Wong, Q., Rich, S. S., de Bakker, P. I. W., McArdle, P. F., Woo, D., Anderson, C. D., Xu, H., Heitsch, L., Fornage, M., Jern, C., Stefansson, K., Thorsteinsdottir, U., Gretarsdottir, S., Lewis, C. M., Sharma, P., Sudlow, C. L. M., Rothwell, P. M., Boncoraglio, G. B., Thijs, V., Levi, C., Meschia, J. F., Rosand, J., Kittner, S. J., Mitchell, B. D., Dichgans, M., Worrall, B. B., Markus, H. S. |
| بيانات النشر: | Wiley |
| سنة النشر: | 2017 |
| المجموعة: | RD&E Research Repository (Royal Devon and Exeter NHS Foundation Trust) |
| مصطلحات موضوعية: | Wessex Classification Subject Headings::Oncology. Pathology.::Genetics |
| الوصف: | Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises a quarter of all ischaemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown younger onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS meta-analysis, including a large younger onset SVS population, to identify novel associations with stroke. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1531-8249 |
| العلاقة: | Genetic Variation at 16q24.2 is associated with small vessel stroke. 2017 Mar;81(3):383-394. Epub 2016 Dec 20. Ann. Neurol.; http://hdl.handle.net/11287/620267Test; Annals of Neurology |
| DOI: | 10.1002/ana.24840 |
| الإتاحة: | https://doi.org/10.1002/ana.24840Test http://hdl.handle.net/11287/620267Test |
| حقوق: | Archived with thanks to Annals of neurology |
| رقم الانضمام: | edsbas.C8CBFA0B |
| قاعدة البيانات: | BASE |
| تدمد: | 15318249 |
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| DOI: | 10.1002/ana.24840 |