دورية أكاديمية
Zinc transporter 8 autoantibody testing requires age-related cut-offs
| العنوان: | Zinc transporter 8 autoantibody testing requires age-related cut-offs |
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| المؤلفون: | Grace, S. L., Cooper, A., Jones, A. G., McDonald, T. J. |
| بيانات النشر: | BMJ |
| سنة النشر: | 2021 |
| المجموعة: | RD&E Research Repository (Royal Devon and Exeter NHS Foundation Trust) |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, 80 and over, Autoantibodies, Cation Transport Proteins/genetics, Child, Preschool, Diabetes Mellitus, Type 1/diagnosis, Type 2, Humans, Infant, Newborn, Middle Aged, Young Adult, Zinc Transporter 8, autoantibodies, autoimmunity, biomarkers, type 1 |
| الوصف: | INTRODUCTION: Zinc transporter 8 autoantibodies (ZnT8A) are biomarkers of beta cell autoimmunity in type 1 diabetes that have become more widely available to clinicians in recent years. Robust control population-defined thresholds are essential to ensure high clinical specificity in islet autoantibody testing. We aimed to determine the optimal cut-offs for ZnT8A testing. RESEARCH DESIGN AND METHODS: 97.5th and 99th centile cut-offs were determined using residual clinical sera from 1559 controls aged between 0 and 83 years with no history of diabetes and a hemoglobin A1c level of less than 6.0% (<42 mmol/mol). ZnT8A were measured by ELISA (RSR, Cardiff, UK) on a Dynex DS2 ELISA robot (Dynex, Preston, UK). We assessed the impact of age-related cut-offs in comparison with the manufacturer's recommended threshold in a mixed cohort of young-onset ( |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://drc.bmj.com/lookup/pmidlookup?view=long&pmid=34348918Test; BMJ Open Diabetes Res Care. 2021 Aug;9(1):e002296. doi:10.1136/bmjdrc-2021-002296.; https://rde.dspace-express.com/handle/11287/622144Test; BMJ open diabetes research & care; PMC8340275 |
| DOI: | 10.1136/bmjdrc-2021-002296 |
| الإتاحة: | https://doi.org/10.1136/bmjdrc-2021-002296Test https://rde.dspace-express.com/handle/11287/622144Test |
| حقوق: | © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. ; http://creativecommons.org/publicdomain/zero/1.0Test/ |
| رقم الانضمام: | edsbas.CBBBBFE1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmjdrc-2021-002296 |
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