دورية أكاديمية
A thyroid hormone-independent molecular fingerprint of 3,5-diiodothyronine suggests a strong relation with coffee metabolism in humans.
| العنوان: | A thyroid hormone-independent molecular fingerprint of 3,5-diiodothyronine suggests a strong relation with coffee metabolism in humans. |
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| المؤلفون: | Pietzner, M., Köhrle, J., Lehmpuhl, I., Budde, K., Kastenmüller, G., Brabant, G., Völzke, H., Artati, A., Adamski, J., Völker, U., Nauck, M., Friedrich, N., Homuth, G. |
| المصدر: | Thyroid 29, 1743-1754 (2019) |
| بيانات النشر: | Mary Ann Liebert, Inc |
| سنة النشر: | 2019 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| مصطلحات موضوعية: | 5-diiodothyronine, Metabolomics, Caffeine Metabolism, Thyroid, Thyrotoxicosis |
| الوقت: | 3 |
| الوصف: | Background: In numerous studies based predominantly on rodent models, administration of 3,5-diiodo-L-thyronine (3,5-T2), a metabolite of the thyroid hormones (TH) thyroxine (T4) and triiodo-L-thyronine (T3), was reported to cause beneficial health effects, including reversal of steatohepatosis and prevention of insulin resistance, in most instances without adverse thyrotoxic side effects. However, the empirical evidence concerning the physiological relevance of endogenously produced 3,5-T2 in humans is comparatively poor. Therefore, to improve the understanding of 3,5-T2-related metabolic processes, we performed a comprehensive metabolomic study relating serum 3,5-T2 concentrations to plasma and urine metabolite levels within a large general population sample. Methods: Serum 3,5-T2 concentrations were determined for 856 participants of the population-based Study of Health in Pomerania-TREND (SHIP-TREND). Plasma and urine metabolome data were generated using mass spectrometry and nuclear magnetic resonance spectroscopy, allowing quantification of 613 and 578 metabolites in plasma and urine, respectively. To detect thyroid function-independent significant 3,5-T2-metabolite associations, linear regression analyses controlling for major confounders, including thyrotropin and free T4, were performed. The same analyses were carried out using a sample of 16 male healthy volunteers treated for 8 weeks with 250 μg/day levothyroxine to induce thyrotoxicosis. Results: The specific molecular fingerprint of 3,5-T2 comprised 15 and 73 significantly associated metabolites in plasma and urine, respectively. Serum 3,5-T2 concentrations were neither associated with classical thyroid function parameters nor altered during experimental thyrotoxicosis. Strikingly, many metabolites related to coffee metabolism, including caffeine and paraxanthine, formed the clearest positively associated molecular signature. Importantly, these associations were replicated in the experimental human thyrotoxicosis model. Conclusion: The molecular ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1050-7256 1557-9077 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31571530; info:eu-repo/semantics/altIdentifier/wos/WOS:0004956187000001; info:eu-repo/semantics/altIdentifier/isbn/1050-7256; info:eu-repo/semantics/alt; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=57375Test; urn:isbn:1050-7256; urn:issn:1050-7256; urn:issn:1557-9077 |
| DOI: | 10.1089/thy.2018.0549 |
| الإتاحة: | https://doi.org/10.1089/thy.2018.0549Test https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=57375Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.93F75DEB |
| قاعدة البيانات: | BASE |
| تدمد: | 10507256 15579077 |
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| DOI: | 10.1089/thy.2018.0549 |