دورية أكاديمية
ImmunoChip study implicates antigen presentation to T cells in narcolepsy.
| العنوان: | ImmunoChip study implicates antigen presentation to T cells in narcolepsy. |
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| المؤلفون: | Faraco, J., Lin, L., Kornum, B.R., Kenny, E.E., Trynka, G., Einen, M., Rico, T.J., Lichtner, P., Dauvilliers, Y., Arnulf, I., Lecendreux, M., Javidi, S., Geisler, P., Mayer, G., Pizza, F., Poli, F., Plazzi, G., Overeem, S., Lammers, G.J., Kemlink, D., Sonka, K., Nevsimalova, S., Rouleau, G., Desautels, A., Montplaisir, J., Frauscher, B., Ehrmann, L., Högl, B., Jennum, P., Bourgin, P., Peraita-Adrados, R., Iranzo, A., Bassetti, C., Chen, W.M., Concannon, P., Thompson, S.D., Damotte, V., Fontaine, B., Breban, M., Gieger, C., Klopp, N., Deloukas, P., Wijmenga, C., Hallmayer, J., Onengut-Gumuscu, S., Rich, S.S., Winkelmann, J., Mignot, E. |
| المصدر: | PLoS Genet. 9:e1003270 (2013) |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2013 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| الوصف: | Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. We genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with hypocretin-deficient narcolepsy and 10,421 controls, all of European ancestry, using a custom genotyping array (ImmunoChip). Three loci located outside the Human Leukocyte Antigen (HLA) region on chromosome 6 were significantly associated with disease risk. In addition to a strong signal in the T cell receptor alpha (TRA@), variants in two additional narcolepsy loci, Cathepsin H (CTSH) and Tumor necrosis factor (ligand) superfamily member 4 (TNFSF4, also called OX40L), attained genome-wide significance. These findings underline the importance of antigen presentation by HLA Class II to T cells in the pathophysiology of this autoimmune disease. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1553-7404 1553-7390 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/23459209; info:eu-repo/semantics/altIdentifier/wos/WOS:000315638300028; info:eu-repo/semantics/altIdentifier/isbn/1553-7404; info:eu-repo/semanti; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=23655Test; urn:isbn:1553-7404; urn:issn:1553-7390; urn:issn:1553-7404 |
| DOI: | 10.1371/journal.pgen.1003270 |
| الإتاحة: | https://doi.org/10.1371/journal.pgen.1003270Test https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=23655Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9A48B6C5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15537404 15537390 |
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| DOI: | 10.1371/journal.pgen.1003270 |