دورية أكاديمية
Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice.
| العنوان: | Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice. |
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| المؤلفون: | Corradi, A., Croci, L., Broccoli, V., Zecchini, S., Previtali, S., Wurst, W., Amadio, S., Maggi, R., Quattrini, A., Consalez, G.G. |
| المصدر: | Development 130, 401-410 (2003) |
| بيانات النشر: | Company of Biologists |
| سنة النشر: | 2003 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| مصطلحات موضوعية: | Olf/Ebf genes, Neurogenesis, Neural development, Neuronal migration, Neuroendocrine, GnRH neurons, Peripheral nerve, Peripheral neuropathy, Dysmyelination, Gene targeting, COE2, O/E3 |
| الوصف: | Olf/Ebf transcription factors have been implicated in numerous developmental processes, ranging from B-cell development to neuronal differentiation. We describe mice that carry a targeted deletion within the EbJ2 (O/E3) gene. In Ebf2-null mutants, because of defective migration of gonadotropin releasing hormone-synthesizing neurons, formation of the neuroendocrine axis (which is essential for pubertal development) is impaired, leading to secondary hypogonadism. In addition, Ebf2(-/-) peripheral nerves feature defective axon sorting, hypomyelination, segmental dysmyelination and axonal damage, accompanied by a sharp decrease in motor nerve conduction velocity. Ebf2-null mice reveal a novel genetic cause of hypogonadotropic hypogonadism and peripheral neuropathy in the mouse, disclosing an important role for Ebf2 in neuronal migration and nerve development. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0950-1991 1477-9129 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/undefined; info:eu-repo/semantics/altIdentifier/isbn/0950-1991; info:eu-repo/semantics/altIdentifier/pissn/0950-1991; info:eu-repo/semantics/altIdentifier/ei; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=2321Test; urn:isbn:0950-1991; urn:issn:0950-1991; urn:issn:1477-9129 |
| DOI: | 10.1242/dev.00215 |
| الإتاحة: | https://doi.org/10.1242/dev.00215Test https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=2321Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.9B6E028F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09501991 14779129 |
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| DOI: | 10.1242/dev.00215 |