التفاصيل البيبلوغرافية
| العنوان: |
The regulation of neuronal progenitor cell migration by cell-cell adhesion factors during zebrafish cerebellar development. |
| المؤلفون: |
Rieger, S. |
| المصدر: |
Diss., 2008, 170 S. |
| سنة النشر: |
2008 |
| المجموعة: |
PuSH - Publikationsserver des Helmholtz Zentrums München |
| مصطلحات موضوعية: |
neuronal migration, cerebellum, cell adhesion, n-cadherin, psa-ncam, polysialyltransferase |
| الوصف: |
Granule progenitor cells (GPCs) in the developing zebrafish cerebellum migrate along chains. Cadherin-2 was found to mediate this chain migration and to function in the establishment and maintenance of GPC polarization, orientation and directional migration along chains. The absence of Cadherin-2 in GPCs leads to their ectopic positioning and cell death. In vivo imaging further revealed that GPCs dynamically re-locate Cadherin-2 while migrating along chains. These findings uncover a key role for zebrafish Cadherin-2 in mediating directional and coherent migration of cerebellar GPCs. PSA is attached to NCAM by two polysialyltransferases STX and PST. Both are expressed in the developing and adult zebrafish cerebellum, where neuronal migration is especially pronounced. Enzymatic degradation of PSA resulted in impaired migration of early neuronal progenitors in the differentiating cerebellum, unraveling a novel function for PSA-NCAM in the regulation of progenitor cell motility. |
| نوع الوثيقة: |
master thesis |
| اللغة: |
English |
| العلاقة: |
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=25073Test |
| الإتاحة: |
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=25073Test |
| حقوق: |
info:eu-repo/semantics/closedAccess |
| رقم الانضمام: |
edsbas.60FB521C |
| قاعدة البيانات: |
BASE |
