دورية أكاديمية
Role of postoperative tumor volume in patients with MGMT-unmethylated glioblastoma.
| العنوان: | Role of postoperative tumor volume in patients with MGMT-unmethylated glioblastoma. |
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| المؤلفون: | Sales, A.H.A., Bette, S., Barz, M., Huber, T., Wiestler, B., Ryang, Y.M., Schmidt-Graf, F., Liesche, F., Combs, S.E., Meyer, B., Gempt, J. |
| المصدر: | J. Neuro-Oncol. 142, 529-536 (2019) |
| بيانات النشر: | Springer |
| سنة النشر: | 2019 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| مصطلحات موضوعية: | Mgmt-methylation, Glioblastoma, Gross-total Resection, Surgery |
| الوصف: | PurposeThe aim of this study is to investigate the association between postoperative tumor volume and overall survival (OS) of O-6-methylguanine DNA methyltransferase (MGMT)-unmethylated glioblastoma patients.MethodsOne hundred-twenty-six patients with MGMT-unmethylated glioblastoma who were treated either with surgical resection or needle biopsy between 2006 and 2015 were included in this retrospective cohort. Pre- and postcontrast T1 weighted images were evaluated in order to determine pre- and postoperative contrast-enhancing tumor volumes (CE-TV). Cox regression models adjusted for other significant prognostic factors were used to investigate the association between postoperative tumor volume and survival.ResultsComplete resection of CE-TV was significantly associated with longer OS in the univariate analysis (HR 0.61; 95% CI 0.40-0.94; p=0.02). However, this fact could not be confirmed after adjusting the model for other relevant prognostic factors (HR 1.01; 95% CI 0.65-1.55; p=0.962). Postoperative CE-TV was significantly associated with survival in both univariate (HR: 1.04; 95% CI 1.025-1.055; p<0.001) and multivariate analyses (HR: 1.027; 95% CI 1.005-1.049; p=0.014).ConclusionsAlthough complete resection of tumor tissue was not significantly associated with longer OS in MGMT-unmethylated GBM patients, maximum safe resection should always be attempted, since postoperative tumor volume is strongly associated with OS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | German |
| تدمد: | 0167-594X 1573-7373 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30790133; info:eu-repo/semantics/altIdentifier/wos/WOS:000465497800016; info:eu-repo/semantics/altIdentifier/isbn/0167-594X; info:eu-repo/semantics; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55956Test; urn:isbn:0167-594X; urn:issn:0167-594X; urn:issn:1573-7373 |
| DOI: | 10.1007/s11060-019-03124-z |
| الإتاحة: | https://doi.org/10.1007/s11060-019-03124-zTest https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55956Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.9F56238E |
| قاعدة البيانات: | BASE |
| تدمد: | 0167594X 15737373 |
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| DOI: | 10.1007/s11060-019-03124-z |